Evidence map›Paper›PMID 32077240›Full record

ArticleDevelopmental neurobiology2019

CD40L reverse signaling suppresses prevertebral sympathetic axon growth and tissue innervation.

Osman Yipkin Calhan, Sean Wyatt, Alun Millward Davies

Open access · hybridAbstract read
In one paragraph

Article in Developmental neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Osman Yipkin CalhanSchool of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0001-5630-6533
Sean WyattSchool of Biosciences, Cardiff University, Cardiff, UK.
Alun Millward DaviesSchool of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0001-5841-8176
Cardiff University · GB

Funding

Wellcome TrustWellcome Trust 103852
6 · The paper itself

Abstract

CD40-activated CD40L reverse signaling is a major physiological regulator of the growth of neural processes in the developing nervous system. Previous work on superior cervical ganglion (SCG) neurons of the paravertebral sympathetic chain has shown that CD40L reverse signaling enhances NGF-promoted axon growth and tissue innervation. Here we show that CD40L reverse signaling has the opposite function in prevertebral ganglion (PVG) sympathetic neurons. During a circumscribed perinatal window of development, PVG neurons cultured from Cd40

Indexed as

AnimalsAxonsCD40 LigandGanglia, SympatheticMice, TransgenicNerve Growth FactorNeuronsSuperior Cervical GanglionCD40 LigandNerve Growth FactorCD40Ldevelopmentinnervationparavertebral sympathetic neuronprevertebral sympathetic neuronreverse signaling

Identifiers

PMID32077240
PMCPMC7187455
OpenAlexW3007888554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.