ArticleEnvironmental science and pollution research international2020
Comparing in vitro cytotoxicity of graphite, short multi-walled carbon nanotubes, and long multi-walled carbon nanotubes.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 25 citations in OpenAlex.
- Recent advances in electroactive biomaterials and electrical stimulation for skeletal muscle regeneration: materials, strategies, and mechanistic insights.Materials today. Bio · 2026Review
- Evaluating the Impact of Carbon Nanoparticles on the Interfacial Properties of the Pulmonary Surfactant Film.Nanomaterials (Basel, Switzerland) · 2025Article
- Study of Printable and Biocompatible Alginate-Carbon Hydrogels for Sensor Applications: Mechanical, Electrical, and Cytotoxicity Evaluation.Gels (Basel, Switzerland) · 2025Article
- Inorganic Nanoparticles: Toxic Effects, Mechanisms of Cytotoxicity and Phytochemical Interactions.Advanced pharmaceutical bulletin · 2022Review
- Review
- Polyurethane Sponge with a Modified Specific Surface for Repeatable Oil-Water Separation.ACS omega · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Occupational and environmental exposures to carbon-based materials in nano- and micro-size have been reported. There is incomplete information on the impact of size on the toxicity of carbon-based materials. The objective of this study is to compare the toxicity of graphite, short multi-walled carbon nanotubes (S-MWCNTs), and long multi-walled carbon nanotubes (L-MWCNTs) in lung cells (A 549). The physicochemical properties of MWCNTs were determined using analytical instruments. The fibers of MWCNTs were dispersed in the sterile-filtered 0.05% bovine serum albumin in MilliQ water. Cytotoxicity of graphite and MWCNTs were assessed using the cell viability, reactive oxygen species (ROS), and lipid peroxidation experiments. Results showed that MWCNTs induced cytotoxicity through the generation of oxidative stress in the exposed lung cells. Mean cytotoxicity of S-MWCNTs was statistically more than that of L-MWCNTs. The graphite induced cytotoxicity only at high concentrations. The mean cytotoxicity of both S-MWCNTs and L-MWCNTs was statistically more than that of graphite. The results also indicated that oxidative stress was the probable toxicity mechanism of carbon-based materials. The decreasing size of carbon-based materials could increase their toxicity. Because of the toxicity of MWCNTs, it is imperative to consider health and safety issues in working with nanomaterials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.