Evidence map›Paper›PMID 32077013›Full record

ArticleProbiotics and antimicrobial proteins2020

In Vitro Evaluation of the Protective Role of Lactobacillus StrainsAgainst Inorganic Arsenic Toxicity.

Gabriela de Matuoka E Chiocchetti, Vicente Monedero, Manuel Zúñiga, Dinoraz Vélez, Vicenta Devesa

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Frontiers in immunology · 2024
    Article
  3. Analysis of gut bacteriome ofFrontiers in microbiology · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gabriela de Matuoka E ChiocchettiInstituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), C. Agustín Escardino 7, 46980, Valencia, Paterna, Spain.
Vicente MonederoInstituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), C. Agustín Escardino 7, 46980, Valencia, Paterna, Spain.
Manuel ZúñigaInstituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), C. Agustín Escardino 7, 46980, Valencia, Paterna, Spain.
Dinoraz VélezInstituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), C. Agustín Escardino 7, 46980, Valencia, Paterna, Spain.
Vicenta DevesaInstituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), C. Agustín Escardino 7, 46980, Valencia, Paterna, Spain. vdevesa@iata.csic.es.ORCID 0000-0002-1988-2985
Instituto de Agroquímica y Tecnología de Alimentos · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inorganic arsenic [iAs, As(III) + As(V)] is considered a human carcinogen. Recent studies show that it has also toxic effects on the intestinal epithelium which might partly explain its systemic toxicity. The aim of this study is to evaluate the protective role of lactic acid bacteria (LAB) against the toxic effects of iAs on the intestinal epithelium. For this purpose, the human colonic cells Caco-2 were exposed to As(III) in the presence of various LAB strains or their conditioned medium. Results showed that some strains and their conditioned media partially revert the oxidative stress, the production of pro-inflammatory cytokines, the alterations of the distribution of tight junction proteins, and the cell permeability increases caused by As(III). These results show that both soluble factors secreted or resulting from LAB metabolism and cell-cell interactions are possibly involved in the beneficial effects. Therefore, some LAB strains have potential as protective agents against iAs intestinal barrier disruption.

Indexed as

Anti-Inflammatory AgentsAntioxidantsArsenicCaco-2 CellsCell Membrane PermeabilityCulture Media, ConditionedFluorescent DyesGene ExpressionHumansInterleukin-8IsoquinolinesLacticaseibacillus caseiLactobacillus acidophilusLevilactobacillus brevisOxidative StressProbioticsAnti-Inflammatory AgentsAntioxidantsArsenicCulture Media, ConditionedFluorescent DyesInterleukin-8Isoquinolineslucifer yellowTJP1 protein, humanZonula Occludens-1 ProteinBarrier disruptionInflammationInorganic arsenicIntestinal epitheliumLactobacillusOxidative stress

Identifiers

PMID32077013
OpenAlexW3008742602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.