Evidence map›Paper›PMID 32076918›Full record

ReviewVirus genes2020

Antivirals in medical biodefense.

J J Bugert, F Hucke, P Zanetta, M Bassetto, A Brancale

Open access · bronzeAbstract readReview
In one paragraph

Review in Virus genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Nucleotide and nucleoside-based drugs: past, present, and future.Saudi journal of biological sciences · 2022
    Review
  7. TheIranian journal of microbiology · 2022
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

J J BugertBundeswehr Institute for Microbiology, Neuherbergstraße 11, 80937, Munich, Germany. Joachim1Bugert@bundeswehr.org.ORCID http://orcid.org/0000-0002-0556-3211
F HuckeBundeswehr Institute for Microbiology, Neuherbergstraße 11, 80937, Munich, Germany.
P ZanettaBundeswehr Institute for Microbiology, Neuherbergstraße 11, 80937, Munich, Germany.
M BassettoDepartment of Chemistry, Swansea University, Swansea, SA2 8PP, UK.
A BrancaleMedicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NB, UK.
Universität der Bundeswehr München · DECardiff University · GBSwansea University · GB

Funding

Bundeswehr STAN 59-2016-01
6 · The paper itself

Abstract

The viruses historically implicated or currently considered as candidates for misuse in bioterrorist events are poxviruses, filoviruses, bunyaviruses, orthomyxoviruses, paramyxoviruses and a number of arboviruses causing encephalitis, including alpha- and flaviviruses. All these viruses are of concern for public health services when they occur in natural outbreaks or emerge in unvaccinated populations. Recent events and intelligence reports point to a growing risk of dangerous biological agents being used for nefarious purposes. Public health responses effective in natural outbreaks of infectious disease may not be sufficient to deal with the severe consequences of a deliberate release of such agents. One important aspect of countermeasures against viral biothreat agents are the antiviral treatment options available for use in post-exposure prophylaxis. These issues were adressed by the organizers of the 16th Medical Biodefense Conference, held in Munich in 2018, in a special session on the development of drugs to treat infections with viruses currently perceived as a threat to societies or associated with a potential for misuse as biothreat agents. This review will outline the state-of-the-art methods in antivirals research discussed and provide an overview of antiviral compounds in the pipeline that are already approved for use or still under development.

Indexed as

Antiviral AgentsArbovirusesBioterrorismFiloviridaeHumansOrthobunyavirusOrthomyxoviridaeParamyxovirinaePoxviridaeVirus DiseasesAntiviral AgentsAntiviralBSL3/4 viral pathogensMedical biodefense

Identifiers

PMID32076918
PMCPMC7089181
OpenAlexW3007786923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.