Evidence map›Paper›PMID 32076665›Full record

ArticleRadiology. Cardiothoracic imaging2019

Sexual Dimorphism of Coronary Artery Disease in a Low- and Intermediate-Risk Asymptomatic Population: Association with Coronary Vessel Wall Thickness at MRI in Women.

Ahmed M Ghanem, Jatin Raj Matta, Reham Elgarf, Ahmed Hamimi, Ranganath Muniyappa, Hadjira Ishaq, Colleen Hadigan, Michael V McConnell, Ahmed M Gharib, Khaled Z Abd-Elmoniem

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ahmed M GhanemBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).
Jatin Raj MattaBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).ORCID 0000-0001-6314-9409
Reham ElgarfBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).
Ahmed HamimiBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).
Ranganath MuniyappaBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).
Hadjira IshaqBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).
Colleen HadiganBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).
Michael V McConnellBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).ORCID 0000-0001-8743-0932
Ahmed M GharibBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).ORCID 0000-0002-2476-481X
Khaled Z Abd-ElmoniemBiomedical and Metabolic Imaging Branch (A.M.G., J.R.M., R.E., A.H., H.I., A.M.G., K.Z.A.) and Diabetes, Endocrinology, and Obesity Branch, Clinical Endocrinology Section (R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 3-5340, MSC 1263, 10 Center Drive, Bethesda, MD 20892; Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (C.H.); Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (M.V.M.); and Cardiovascular Health Innovations, Verily Life Sciences/Alphabet, South San Francisco, Calif (M.V.M.).ORCID 0000-0002-1001-1702
National Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo demonstrate the association between coronary vessel wall thickness (VWT) measured at MRI and coronary artery disease (CAD) risk in asymptomatic groups at low and intermediate risk on the basis of Framingham score. MATERIALS AND

methodsA total of 131 asymptomatic adults were prospectively enrolled. All participants underwent CT angiography for scoring CAD, and coronary VWT was measured at 3.0-T MRI. Nonlinear single and multivariable regression analyses with consideration for interaction with sex were performed to investigate the association of traditional atherosclerotic risk factors and VWT with CT angiography-based CAD scores.

resultsThe analysis included 62 women and 62 men with low or intermediate Framingham score of less than 20%. Age (mean age, 45.0 years ± 14.5 [standard deviation]) and body mass index were not different between the groups. Age, sex, and VWT were individually significantly associated with all CT angiography-based CAD scores (

conclusionIn asymptomatic women, VWT MRI was the primary independent surrogate of CAD, whereas age was the strongest risk factor in men. This study suggests that VWT may be used as a CAD surrogate in women at low or intermediate risk of CAD. Further longitudinal studies are required to determine the potential implication and use of this MRI technique for the preventative management of CAD in women.© RSNA, 2019.

Identifiers

PMID32076665
PMCPMC6555440
OpenAlexW2940591640

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.