Evidence map›Paper›PMID 32076635›Full record

ArticleScience advances2020

A single-nucleotide polymorphism in a

Munir Akkaya, Abhisheka Bansal, Patrick W Sheehan, Mirna Pena, Alvaro Molina-Cruz, Lindsey M Orchard, Clare K Cimperman, Chen-Feng Qi, Philipp Ross, Takele Yazew and 8 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  6. Declines in prevalence alter the optimal level of sexual investment for the malaria parasiteProceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Munir AkkayaLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-9949-9424
Abhisheka BansalLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Patrick W SheehanLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-8476-6246
Mirna PenaLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Alvaro Molina-CruzLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-5137-4836
Lindsey M OrchardDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0003-1295-3733
Clare K CimpermanLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Chen-Feng QiLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Philipp RossDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.
Takele YazewLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-6179-0796
Daniel SturdevantResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Sarah L AnzickResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Girija ThiruvengadamLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0001-7942-3943
Thomas Dan OttoWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-1246-7404
Oliver BillkerDepartment of Molecular Biology, Umeå University, S-90187 Umeå, Sweden.ORCID 0000-0003-1716-168X
Manuel LlinásDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-6173-5882
Louis H MillerLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Susan K PierceLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-7386-9589
National Institutes of Health · USPennsylvania State University · USUmeå University · SEWellcome Sanger Institute · GB

Funding

Mali International Center for Excellence in Research: Malaria immunologyZIAAI001064 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI PIERCE, SUSAN · 2009 to 2025
$25.1M
Malaria Parasite Receptors And Host Cell LigandsZIAAI000241 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MILLER, LOUIS · 2009 to 2025
$15.3M
Dissecting the role of ApiAP2 proteins in transcriptional regulation during Plasmodium falciparum developmentR01AI125565 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI LLINAS, MANUEL · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI125565
6 · The paper itself

Abstract

The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite

Indexed as

ImmunityPolymorphism, Single NucleotideAdaptive ImmunityAnimalsCulicidaeDNA-Binding ProteinsHost-Parasite InteractionsMalariaPlasmodium bergheiProtein Interaction Domains and MotifsTh1 CellsTranscription Factor AP-2DNA-Binding ProteinsTranscription Factor AP-2

Identifiers

PMID32076635
PMCPMC7002124
OpenAlexW3004969079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.