ArticleAcute medicine & surgery
Epidemiology and volume-outcome relationship of extracorporeal membrane oxygenation for respiratory failure in Japan: A retrospective observational study using a national administrative database.
Article in Acute medicine & surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Human factors in ECLS - A keystone for safety and quality - A narrative review for ECLS providers.Artificial organs · 2022Pooled it
- Process Analysis of Neonatal and Pediatric Respiratory Extracorporeal Membrane Oxygenation Referrals: An 8-Year Experience at a High-Volume Center.Critical care explorations · 2026Article
- Extracorporeal life support for adult patients with ARDS.Intensive care medicine · 2025Review
- Hospital-level volume in extracorporeal membrane oxygenation cases and death or disability at 6 months.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Analysis of adverse events related to extracorporeal membrane oxygenation from a nationwide database of patient-safety accidents in Japan.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Article
- Epidemiology of ischemic stroke and hemorrhagic stroke in venoarterial extracorporeal membrane oxygenation.Critical care (London, England) · 2023Article
- Prolonged VV ECMO: Navigating the Unchartered Sea.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Long-Term Outcomes of Extracorporeal Life Support in Respiratory Failure.Journal of clinical medicine · 2023Review
- Waitlist Mortality and Extracorporeal Membrane Oxygenation Bridge to Lung Transplant.The Annals of thoracic surgery · 2023Article
- Effect of hospital case volume on clinical outcomes of patients requiring extracorporeal membrane oxygenation: a territory-wide longitudinal observational study.Journal of thoracic disease · 2022Article
- Extracorporeal membrane oxygenation (ECMO) support for acute hypoxemic respiratory failure patients: outcomes and predictive factors.Journal of thoracic disease · 2022Article
- Procedural volume and outcomes in patients undergoing VA-ECMO support.Critical care (London, England) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo describe the epidemiology of patients on extracorporeal membrane oxygenation (ECMO) and investigate the possible association between outcomes for respiratory ECMO patients and hospital volume of ECMO treatment for any indications.
methodsUsing data from the Diagnosis Procedure Combination database, a nationwide Japanese inpatient database, between 1 July 2010 and 31 March 2018, we identified inpatients aged ≥18 years who underwent ECMO. Institutional case volume was defined as the mean annual number of ECMO cases; eligible patients were categorized into institutional case volume tertile groups. The primary outcome was in-hospital mortality. For ECMO patients with respiratory failure, the association between institutional case volume group and in-hospital mortality rate was analyzed using a multilevel logistic regression model including multiple imputation.
resultsExtracorporeal membrane oxygenation was carried out on 25,384 patients during the study period; of those, 1,227 cases were for respiratory failure. Respiratory cases were categorized into low- (<8 cases/year), medium- (8-16 cases/year), and high-volume groups (≥17 cases/year). The overall in-hospital mortality rate for respiratory ECMO was 62.5% in low-, 54.7% in medium-, and 50.4% in high-volume institutions. With reference to low-volume institutions, the adjusted odds ratios (95% confidence interval) of the medium- and high-volume institutions for in-hospital mortality were 0.72 (0.50-1.04;
conclusionsThe present study showed that accumulating the experience of using ECMO for any indications could positively affect the outcome of ECMO treatment for respiratory failure, which suggests the effectiveness of consolidating ECMO cases in high-volume centers in Japan.
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