ArticleEcology and evolution2020
Important role of genetic drift in rapid polygenic adaptation.
Article in Ecology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Polygenic and monogenic adaptation drive evolutionary rescue at different magnitudes of environmental change.The Journal of heredity · 2026Article
- A theory of oligogenic adaptation of a quantitative trait.Genetics · 2023Article
- Species-wide genomics of kākāpō provides tools to accelerate recovery.Nature ecology & evolution · 2023Article
- On the genetic architecture of rapidly adapting and convergent life history traits in guppies.Heredity · 2022Article
- The evolution of larger size in high-altitude Drosophila melanogaster has a variable genetic architecture.G3 (Bethesda, Md.) · 2022Article
- Using singleton densities to detect recent selection inEvolution letters · 2021Article
- Ethanol resistance inEcology and evolution · 2021Article
- Rapid Evolutionary Adaptation in Response to Selection on Quantitative Traits.Life (Basel, Switzerland) · 2021Review
- Polygenic basis for adaptive morphological variation in a threatened Aotearoa | New Zealand bird, the hihi (Proceedings. Biological sciences · 2020Article
- Polygenic Adaptation in a Population of Finite Size.Entropy (Basel, Switzerland) · 2020Review
- Important role of genetic drift in rapid polygenic adaptation.Ecology and evolution · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed a model to determine the factors that facilitate or limit rapid polygenic adaptation. This model includes population genetic terms of mutation and both directional and stabilizing selection on a highly polygenic trait in a diploid population of finite size. First, we derived the equilibrium distribution of the allele frequencies of the multilocus model by diffusion approximation. This formula describing the equilibrium allele frequencies as a mutation-selection-drift balance was examined by computer simulation using parameter values inferred for human height, a well-studied polygenic trait. Second, assuming that a sudden environmental shift of the fitness optimum occurs while the population is in equilibrium, we analyzed the adaptation of the trait to the new optimum. The speed at which the trait mean approaches the new optimum increases with the equilibrium genetic variance. Thus, large population size and/or large mutation rate may facilitate rapid adaptation. Third, the contribution of an individual locus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.