ArticleWorld journal of emergency medicine2020
Effect of neutrophil CD64 for diagnosing sepsis in emergency department.
Article in World journal of emergency medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Diagnostic performance of Neutrophil CD64 index, procalcitonin, and C-reactive protein for early sepsis in hematological patients.World journal of clinical cases · 2022Trial
- Recent advances in the biosensing platforms for sepsis diagnosis.RSC advances · 2026Review
- Clinical Value the Neutrophil CD64 Index in Predicting the Severity of Hemorrhagic Fever With Renal Syndrome.Immunity, inflammation and disease · 2026Article
- Diagnostic and prognostic utility of neutrophil CD64 and monocyte HLA-DR in adult sepsis patients.BMC research notes · 2026Observational
- Sepsis as a complex syndrome: Are combined biomarkers the future of diagnosis and prognosis? Clinical perspective.Immunology letters · 2026Review
- Mesenchymal Stem Cell-Derived Exosomes in Anti-NET Therapy: Mechanisms, Challenges, and Future Perspectives.International journal of nanomedicine · 2025Review
- Effector function and neutrophil cell death in the severity of sepsis with diabetes mellitus.Narra J · 2024Review
- An integrative model with HLA-DR, CD64, and PD-1 for the diagnostic and prognostic evaluation of sepsis.Immunity, inflammation and disease · 2024Observational
- Restoring the infected powerhouse: Mitochondrial quality control in sepsis.Redox biology · 2023Review
- Diagnostic Value of Neutrophil CD64 in Sepsis Patients in the Intensive Care Unit: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2023Article
- The Value of Peripheral Blood Leukocyte Parameters in the Early Diagnosis and Clinical Prognosis of Sepsis.International journal of analytical chemistry · 2023Article
- Neutrophil CD64-a prognostic marker of sepsis in intensive care unit: a prospective cohort study.Frontiers in medicine · 2023Article
- Cytokine Storm-Definition, Causes, and Implications.International journal of molecular sciences · 2022Review
- Pathophysiology of Sepsis and Genesis of Septic Shock: The Critical Role of Mesenchymal Stem Cells (MSCs).International journal of molecular sciences · 2022Review
- Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review.Critical care (London, England) · 2022Review
- Initial venous lactate levels as a predictor of mortality in severe sepsis: a single-center retrospective cohort study.World journal of emergency medicine · 2022Article
- Intestinal microcirculation dysfunction in sepsis: pathophysiology, clinical monitoring, and therapeutic interventions.World journal of emergency medicine · 2022Review
- Diagnostic Challenges in Sepsis.Current infectious disease reports · 2021Review
- Host Diagnostic Biomarkers of Infection in the ICU: Where Are We and Where Are We Going?Current infectious disease reports · 2021Review
- Effects of viral infection and microbial diversity on patients with sepsis: A retrospective study based on metagenomic next-generation sequencing.World journal of emergency medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to investigate the diagnostic and prognostic value of neutrophil CD64 (nCD64) as a novel biomarker in sepsis patients.
methodsOne hundred fifty-one adult patients diagnosed with sepsis and 20 age-matched healthy controls were enrolled in the study. Patients with sepsis were further subdivided into a sepsis group and a septic shock group. nCD64 expression, serum procalcitonin (PCT) level, C-reactive protein (CRP) level, and white blood cell (WBC) count were obtained for each patient, and Sequential Organ Failure Assessment (SOFA) scores were calculated.
resultsnCD64 expression was higher in the sepsis group with confirmed infection than in the control group. The receiver operating characteristic (ROC) curve of nCD64 was higher than those of SOFA score, PCT, CRP and WBC for diagnosing infection. The area under the curve (AUC) of nCD64 combined with SOFA score was the highest for all parameters. The AUC of nCD64 for predicting 28-day mortality in sepsis was significantly higher than those of PCT, CRP, and WBC, but slightly lower than that of SOFA score. The AUC of nCD64 or PCT combined with SOFA score was significantly higher than that of any single parameter for predicting 28-day mortality.
conclusionnCD64 expression and SOFA score are valuable parameters for early diagnosis of infection and prognostic evaluation of sepsis patients.
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