Evidence map›Paper›PMID 32076469›Full record

ReviewCanadian respiratory journal2020

Postinfectious Bronchiolitis Obliterans in Children: Diagnostic Workup and Therapeutic Options: A Workshop Report.

Silvija-Pera Jerkic, Folke Brinkmann, Alistair Calder, Alicia Casey, Megan Dishop, Matthias Griese, Geoffrey Kurland, Mandy Niemitz, Sylvia Nyilas, Dirk Schramm and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Canadian respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 4 countries.

Silvija-Pera JerkicDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany.ORCID 0000-0003-2972-649X
Folke BrinkmannDepartment of Paediatric Pneumology, Children's Hospital, Ruhr University of Bochum, Bochum, Germany.
Alistair CalderRadiology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Alicia CaseyBoston Children's Hospital, Harvard Medical School, Boston, USA.ORCID 0000-0002-3566-9690
Megan DishopDivision of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, USA.
Matthias GrieseDepartment of Pediatric Pneumology, Dr. von Hauner Children's Hospital, LMU Munich, German Center for Lung Research (DZL), Munich, Germany.
Geoffrey KurlandDivision of Pediatric Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Mandy NiemitzUniversity of Ulm Medical Centre, Clinic for Child and Adolescent Psychiatry/Psychotherapy, Ulm, Germany.
Sylvia NyilasDivision of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, University of Bern, Bern, Switzerland.
Dirk SchrammDepartment of General Pediatrics, University Children's Hospital, Düsseldorf, Germany.
Ralf SchubertDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany.
Michael TammDepartment of Pulmonary Medicine, University Hospital Basel, Basel, Switzerland.
Stefan ZielenDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany.ORCID 0000-0003-1204-0627
Martin RosewichDivision for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe-University, Frankfurt/Main, Germany.
Goethe University Frankfurt · DEBoston Children's Hospital · USDüsseldorf University Hospital · DEGerman Center for Lung Research · DEGreat Ormond Street Hospital for Children NHS Foundation Trust · GBPhoenix Children's Hospital · USUniversität Ulm · DEUniversity Hospital of Basel · CHUniversity Hospitals of the Ruhr-University of Bochum · DEUniversity of Bern · CHUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bronchiolitis obliterans (BO) is a rare, chronic form of obstructive lung disease, often initiated with injury of the bronchiolar epithelium followed by an inflammatory response and progressive fibrosis of small airways resulting in nonuniform luminal obliteration or narrowing. The term BO comprises a group of diseases with different underlying etiologies, courses, and characteristics. Among the better recognized inciting stimuli leading to BO are airway pathogens such as adenovirus and mycoplasma, which, in a small percentage of infected children, will result in progressive fixed airflow obstruction, an entity referred to as postinfectious bronchiolitis obliterans (PIBO). The present knowledge on BO in general is reasonably well developed, in part because of the relatively high incidence in patients who have undergone lung transplantation or bone marrow transplant recipients who have had graft-versus-host disease in the posttransplant period. The cellular and molecular pathways involved in PIBO, while assumed to be similar, have not been adequately elucidated. Since 2016, an international consortium of experts with an interest in PIBO assembles on a regular basis in Geisenheim, Germany, to discuss key areas in PIBO which include diagnostic workup, treatment strategies, and research fields.

Indexed as

Bronchiolitis ObliteransDiagnostic Techniques, Respiratory SystemChildHumansPatient Care ManagementRespiratory Tract Infections

Identifiers

PMID32076469
PMCPMC7013295
OpenAlexW3004281864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.