Evidence map›Paper›PMID 32076458›Full record

ArticleDisease markers2020

Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis.

Lu Zhang, Huihui Li, Ming Yuan, Dong Li, Chang Sun, Guoyun Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 8 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 8 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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  5. Expression ofInternational journal of molecular sciences · 2023
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  6. Liquid Biopsy in Endometriosis: A Systematic Review.International journal of molecular sciences · 2023
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lu ZhangDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, NO.107 Wenhuaxi Road, Jinan, Shandong 250012, China.ORCID https://orcid.org/0000-0002-3865-9498
Huihui LiDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, NO.107 Wenhuaxi Road, Jinan, Shandong 250012, China.
Ming YuanDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, NO.107 Wenhuaxi Road, Jinan, Shandong 250012, China.
Dong LiCryomedicine Lab, Qilu Hospital of Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-6496-4605
Chang SunSchool of Material Science and Engineering, Shandong Jianzhu University, Jinan 250101, China.
Guoyun WangDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, NO.107 Wenhuaxi Road, Jinan, Shandong 250012, China.ORCID https://orcid.org/0000-0003-4023-084X
Qilu Hospital of Shandong University · CNShandong Jianzhu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA reliable noninvasive biomarker is not yet available for endometriosis diagnosis. Novel biomarkers for the diagnosis of endometriosis are urgently needed. The molecular constituents of exosomes, especially exosomal microRNAs (miRNAs), have considerable potential as novel biomarkers for clinical diagnosis. This study is aimed at exploring aberrant exosomal miRNA profiles by using miRNA microarray and at providing more accurate molecular biomarkers of endometriosis.

methodsExosomes were isolated from the serum of patients with endometriosis and negative controls and identified by electron microscopy, nanoparticle tracking analysis, and Western blot. Exosomal miRNAs were profiled by miRNA microarrays. The expression of selective serum exosomal miRNA was validated by qRT-PCR. Receiver operating characteristic (ROC) curves were established to explore the diagnostic value of selective miRNAs. Finally, GO annotation and KEGG pathway enrichment analyses were used to display possible functions associated with the two miRNAs.

resultsA total of 24 miRNAs showed differential levels of enrichment with

conclusionOur results demonstrated that exosomal miR-22-3p and miR-320a were significantly increased in the sera of patients with endometriosis. The two miRNAs may be useful potential biomarkers for endometriosis diagnosis.

Indexed as

AdultArea Under CurveBiomarkers, TumorCase-Control StudiesEndometriosisExosomesFemaleGene Expression ProfilingHumansMicroRNAsMiddle AgedOligonucleotide Array Sequence AnalysisUp-RegulationYoung AdultBiomarkers, TumorMicroRNAsMIRN22 microRNA, humanMIRN320 microRNA, human

Identifiers

PMID32076458
PMCPMC7008302
OpenAlexW3004120044

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.