Evidence map›Paper›PMID 32076268›Full record

ArticleNature2020

Gene expression and cell identity controlled by anaphase-promoting complex.

Eugene Oh, Kevin G Mark, Annamaria Mocciaro, Edmond R Watson, J Rajan Prabu, Denny D Cha, Martin Kampmann, Nathan Gamarra, Coral Y Zhou, Michael Rape

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
7.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Hematopoietic Stem Cell Hierarchies as Novel Biomarkers of Drug Response in Myelodysplastic Syndromes and Acute Myeloid Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  10. Article
  11. Article
  12. An E2 ubiquitin-conjugating enzyme links diubiquitinated H2B to H3K27M oncohistone function.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Eugene Oh *Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Kevin G Mark *Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Annamaria MocciaroHoward Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Edmond R WatsonDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.
J Rajan PrabuDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.
Denny D ChaHoward Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Martin KampmannDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA.
Nathan GamarraDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA.
Coral Y ZhouDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA.
Michael RapeHoward Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA. mrape@berkeley.edu.
University of California, Berkeley · USMax Planck Institute of Biochemistry · DEUniversity of California, San Francisco · USChan Zuckerberg Initiative (United States) · USHoward Hughes Medical Institute · US

Funding

Dissecting Mechanisms of Ubiquitination and Deubiquitination in Cell Cycle ControR01GM083064 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAPE, MICHAEL P · 2008 to 2016
$2.2M
Role of Ubiquitination in Neurocristopathies and Neural Crest-Derived CancersF32GM120956 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MARK, KEVIN · 2016 to 2018
$174k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM120956NIGMS NIH HHS R01 GM083064
6 · The paper itself

Abstract

Metazoan development requires the robust proliferation of progenitor cells, the identities of which are established by tightly controlled transcriptional networks

Indexed as

Gene Expression RegulationAnaphaseAnaphase-Promoting Complex-CyclosomeCell DifferentiationCell DivisionHEK293 CellsHeLa CellsHistonesHuman Embryonic Stem CellsHumansInterphaseIntracellular Signaling Peptides and ProteinsMitosisMultiprotein ComplexesOrganophosphatesPolyubiquitinAnaphase-Promoting Complex-CyclosomeHistonesIntracellular Signaling Peptides and ProteinsMultiprotein ComplexesOrganophosphatesPolyubiquitinProteasome Endopeptidase Complextributyl phosphateUbiquitinWDR5 protein, human

Identifiers

PMID32076268
PMCPMC7402266
OpenAlexW3007614199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.