Evidence map›Paper›PMID 32076265›Full record

ArticleNature2020

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis.

Bo Hu, Chengcheng Jin, Xing Zeng, Jon M Resch, Mark P Jedrychowski, Zongfang Yang, Bhavna N Desai, Alexander S Banks, Bradford B Lowell, Diane Mathis and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 170 citations in OpenAlex.

  1. Review
  2. DICER-driven regulation of lipid metabolism and macrophage-adipocyte crosstalk in partial lipodystrophy.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Bo Hu *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Chengcheng Jin *Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Xing Zeng *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jon M ReschDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Mark P JedrychowskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Zongfang YangDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Bhavna N DesaiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Alexander S BanksDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Bradford B LowellDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Bruce M SpiegelmanDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu.
Harvard University · USBeth Israel Deaconess Medical Center · USDana-Farber Cancer Institute · USUniversity of Pennsylvania · US

Funding

CONTROL OF ADIPOCYTE GENE EXPRESSION AND PHYSIOLOGYR37DK031405 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1996 to 2013
$8.2M
Adipose-tissue Tregs: important players in immunological control of metabolismR01DK092541 · NIDDK · HARVARD MEDICAL SCHOOL · PI DIANE J MATHIS · 2011 to 2026
$6.4M
Super-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2011 to 2020
$5.8M
CONTROL OF LIPOGENIC ENZYME SYNTHESIS IN ADIPOCYTESR01DK031405 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1986 to 2018
$2.9M
Investigating immune-microbiota interaction in lung cancerR00CA226400 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JIN, CHENGCHENG · 2020 to 2022
$866k
Investigating immune-microbiota interaction in lung cancerK99CA226400 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JIN, CHENGCHENG · 2018 to 2019
$252k
NCI NIH HHS K99 CA226400NCI NIH HHS R00 CA226400NIDDK NIH HHS R01 DK031405NIDDK NIH HHS R01 DK092541NIDDK NIH HHS R37 DK031405NINDS NIH HHS P30 NS072030
6 · The paper itself

Abstract

The sympathetic nervous system innervates peripheral organs to regulate their function and maintain homeostasis, whereas target cells also produce neurotrophic factors to promote sympathetic innervation

Indexed as

ThermogenesisAdipocytesAdipose TissueAdipose Tissue, BrownAnimalsInterleukin-17MaleMiceMice, KnockoutOrgan SpecificityParenchymal TissueSignal TransductionSympathetic Nervous SystemT-LymphocytesTransforming Growth Factor beta1Il17c protein, mouseInterleukin-17Tgfb1 protein, mouseTransforming Growth Factor beta1

Identifiers

PMID32076265
PMCPMC7055484
OpenAlexW3008967181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.