Evidence map›Paper›PMID 32076107›Full record

ArticleScientific reports2020

New signatures of poor CD4 cell recovery after suppressive antiretroviral therapy in HIV-1-infected individuals: involvement of miR-192, IL-6, sCD14 and miR-144.

Francisco Hernández-Walias, María J Ruiz-de-León, Isaac Rosado-Sánchez, Esther Vázquez, Manuel Leal, Santiago Moreno, Francesc Vidal, Julià Blanco, Yolanda M Pacheco, Alejandro Vallejo

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  5. miR-144/451: A Regulatory Role in Inflammation.Current molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Francisco Hernández-Walias *Laboratory of Immunovirology, Department of Infectious Diseases. Health Research Institute Ramon y Cajal (IRyCIS), University Hospital Ramon y Cajal, Madrid, Spain.
María J Ruiz-de-León *Laboratory of Immunovirology, Department of Infectious Diseases. Health Research Institute Ramon y Cajal (IRyCIS), University Hospital Ramon y Cajal, Madrid, Spain.
Isaac Rosado-SánchezBiomedicine Institute of Seville (IBiS), University Hospital Virgen del Rocío, Seville, Spain.
Esther VázquezLaboratory of Immunovirology, Department of Infectious Diseases. Health Research Institute Ramon y Cajal (IRyCIS), University Hospital Ramon y Cajal, Madrid, Spain.
Manuel LealBiomedicine Institute of Seville (IBiS), University Hospital Virgen del Rocío, Seville, Spain.
Santiago MorenoLaboratory of Immunovirology, Department of Infectious Diseases. Health Research Institute Ramon y Cajal (IRyCIS), University Hospital Ramon y Cajal, Madrid, Spain.
Francesc VidalInfectious Diseases Unit and HIV/AIDS, Department of Internal Medicine, University Hospital Joan XXIII, IISPV, University Rovira i Virgili, Tarragona, Catalonia, Spain.
Julià BlancoAIDS Research Institute IrsiCaixa-HIVACAT, Research Institute of Health Sciences Germans Trias i Pujol, Badalona, Catalonia, Spain.
Yolanda M PachecoBiomedicine Institute of Seville (IBiS), University Hospital Virgen del Rocío, Seville, Spain. ypacheco-ibis@us.es.
Alejandro VallejoLaboratory of Immunovirology, Department of Infectious Diseases. Health Research Institute Ramon y Cajal (IRyCIS), University Hospital Ramon y Cajal, Madrid, Spain. alejandro.vallejo@salud.madrid.org.
Instituto Cajal · ESInstituto de Biomedicina de Sevilla · ESInstitut d'Investigació Sanitària Pere Virgili · ESUniversitat de Vic - Universitat Central de Catalunya · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to 40% of newly diagnosed cases of HIV-1 infection are late diagnoses, with a profound decrease in CD4 cell counts in many cases. One-third of these individuals do not achieve optimal CD4 cell recovery (OR) after suppressive antiretroviral treatment (ART). This retrospective/longitudinal study of poor recovery (PR) included 79 HIV-1-infected individuals with CD4 count <200 cells/mm

Indexed as

Antiretroviral Therapy, Highly ActiveAdultCD4-Positive T-LymphocytesExosomesFemaleHIV InfectionsHumansInterleukin-6Lipopolysaccharide ReceptorsMaleMicroRNAsMiddle AgedMultivariate AnalysisPredictive Value of TestsROC CurveSolubilityInterleukin-6Lipopolysaccharide ReceptorsMicroRNAsMIRN144 microRNA, humanMIRN192 microRNA, human

Identifiers

PMID32076107
PMCPMC7031287
OpenAlexW3008504135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.