ArticleNature communications2020
Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Pd(II)-NHC (NHC = N-Heterocyclic Carbene)-Catalyzed Alkylation of Primary Amides by Site-Selective N─C(O) Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Organocatalyzed atroposelective dynamic kinetic resolutions via transient seven-membered cyclic hemiacetals.Science advances · 2025Article
- A multifunctional trap-capture-kill antibacterial system for enhanced wound healing via modified decellularized mushroom aerogels.Bioactive materials · 2025Article
- An analysis method including orbital overlap directions for predicting π electron properties and reactivity vectors.Nature communications · 2025Article
- Recent advances in organocatalytic atroposelective reactions.Beilstein journal of organic chemistry · 2025Review
- Synthesis of Novel Planar-Chiral Charge-CompensatedMolecules (Basel, Switzerland) · 2024Article
- Atroposelective catalysis.Nature reviews. Chemistry · 2024Review
- Amide C-N bonds activation by A new variant of bifunctional N-heterocyclic carbene.Nature communications · 2024Article
- Dirhodium(II)/Phosphine Catalyst with Chiral Environment at Bridging Site and Its Application in Enantioselective Atropisomer Synthesis.ACS central science · 2023Article
- Hypervalent iodine-promoted twofold oxidative coupling of amines with amides and thioamides: chemoselective pathway to oxazoles and thiazoles.Chemical science · 2023Article
- Recent Progress in Cyclic Aryliodonium Chemistry: Syntheses and Applications.Chemical reviews · 2023Review
- Desymmetrization of N-Cbz glutarimides through N-heterocyclic carbene organocatalysis.Nature communications · 2022Article
- Cu(i) catalysis for selective condensation/bicycloaromatization of two different arylalkynes: direct and general construction of functionalized C-N axial biaryl compounds.Chemical science · 2021Article
- Electrochemical Organic Synthesis of Electron-Rich Biaryl Scaffolds: An Update.Molecules (Basel, Switzerland) · 2021Review
- Desymmetrization of Cyclic 1,3-Diketones underResearch (Washington, D.C.) · 2021Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Amides are among the most fundamental functional groups and essential structural units, widely used in chemistry, biochemistry and material science. Amide synthesis and transformations is a topic of continuous interest in organic chemistry. However, direct catalytic asymmetric activation of amide C-N bonds still remains a long-standing challenge due to high stability of amide linkages. Herein, we describe an organocatalytic asymmetric amide C-N bonds cleavage of N-sulfonyl biaryl lactams under mild conditions, developing a general and practical method for atroposelective construction of axially chiral biaryl amino acids. A structurally diverse set of axially chiral biaryl amino acids are obtained in high yields with excellent enantioselectivities. Moreover, a variety of axially chiral unsymmetrical biaryl organocatalysts are efficiently constructed from the resulting axially chiral biaryl amino acids by our present strategy, and show competitive outcomes in asymmetric reactions.
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