ArticleNature communications2020
Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
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- A nutrient bottleneck controls antibiotic efficacy in structured bacterial populations.Nature communications · 2026Article
- The archibiome: extending engineered living materials to multiscale built environments.Frontiers in systems biology · 2026Article
- Understanding the development of bacterial colony: Physiology, new technology, and modeling.Quantitative biology (Beijing, China) · 2025Review
- Towards the control of biofilm formation in Anabaena (Nostoc) sp. PCC7120: novel insights into the genes involved and their regulation.The New phytologist · 2025Article
- Protein Homeostasis Impairment Alters Phenotypic Heterogeneity of Biofilm Communities.Molecular microbiology · 2025Article
- Changes in Spo0A~P pulsing frequency control biofilm matrix deactivation.PLoS computational biology · 2025Article
- Pulsatile basal gene expression as a fitness determinant in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Colony pattern multistability emerges from a bistable switch.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intrinsically robust and scalable biofilm segmentation under diverse physical growth conditions.iScience · 2024Article
- High-throughput single-cell transcriptomics of bacteria using combinatorial barcoding.Nature protocols · 2024Review
- Information content and optimization of self-organized developmental systems.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spatial transcriptome uncovers rich coordination of metabolism in E. coli K12 biofilm.Nature chemical biology · 2023Article
- The σB alternative sigma factor circuit modulates noise to generate different types of pulsing dynamics.PLoS computational biology · 2023Article
- Advances in linking single-cell bacterial stress response to population-level survival.Current opinion in biotechnology · 2023Review
- Navigating Environmental Transitions: the Role of Phenotypic Variation in Bacterial Responses.mBio · 2022Review
- Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective.Open biology · 2022Review
- A Noninvasive Method for Time-Lapse Imaging of Microbial Interactions and Colony Dynamics.Microbiology spectrum · 2022Article
- To biofilm or not to biofilm.eLife · 2022Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells, but it is unclear whether it has a role in the development of multicellular systems. Here, we show how stochastic pulsing of gene expression enables spatial patterns to form in a model multicellular system, Bacillus subtilis bacterial biofilms. We use quantitative microscopy and time-lapse imaging to observe pulses in the activity of the general stress response sigma factor σ
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