ArticleNature communications2020
A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
94 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Macroscale Gradient Dysfunction in Alzheimer's Disease: Patterns With Cognition Terms and Gene Expression Profiles.Human brain mapping · 2024Pooled it
- Hippocampus long-axis specialization throughout development: A meta-analysis.Human brain mapping · 2023Pooled it
- Adeno-Associated Virus Vector-Mediated Expression of Neuroligin 2 in the Mouse Hippocampus Attenuates the Progression of Pentylenetetrazol-Induced Seizures.The journal of gene medicine · 2026Article
- Predicted brain-regional gene expression patterns in individuals living with Alzheimer's disease.Neurobiology of aging · 2026Article
- Selective convergence and graded divergence of hippocampal and amygdala subregions using functional connectivity.bioRxiv : the preprint server for biology · 2026Article
- Cingulate Gradient Dysfunction in End-Stage Renal Disease: Associations With Clinical Phenotypes and Exploratory Transcriptomic Signatures.CNS neuroscience & therapeutics · 2026Article
- The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.Nature communications · 2026Article
- Hippocampal Long Axis Differentiation in Memory and Seizure Networks.Epilepsy currents · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- An anatomical and connectivity atlas of the tree shrew brain to bridge rodent and primate neuroanatomy.PLoS biology · 2026Article
- Insulin-like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis.Epilepsia · 2026Article
- Translating brain anatomy and disease from mouse to human in latent gene expression space.EBioMedicine · 2026Article
- Integrating optogenetic fMRI and spatial transcriptomics to reveal circuit-specific gene signatures in fronto- and hippo-thalamic networks.Nature communications · 2026Article
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- Effects of combined prenatal exposure to air pollution and maternal stress on immune and dopaminergic gene expression in the gut-brain axis.Brain, behavior, & immunity - health · 2026Article
- Map-like representations of emotion knowledge in hippocampal-prefrontal systems.Nature communications · 2026Article
- Imaging spatial transcriptomics reveals molecular patterns underlying accumulation of p-Ser129 α-synuclein in a transgenic mouse model.NPJ Parkinson's disease · 2026Article
- The hippocampal subgranular zone neurogenic niche: a modular perspective on neural stem cell regulation.Frontiers in cellular neuroscience · 2026Review
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.bioRxiv : the preprint server for biology · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the longitudinal axis of the adult human hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. Futhermore, this model generalizes to an external set of tissue samples from prenatal human hippocampi. We examine variation in this specific gene expression pattern across the whole brain, finding a distinct anterioventral-posteriodorsal gradient. We find frontal and anterior temporal regions involved in social and motivational behaviors, and more functionally connected to the anterior hippocampus, to be clearly differentiated from posterior parieto-occipital regions involved in visuospatial cognition and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a single molecular gradient.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.