Evidence map›Paper›PMID 32075915›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ.

Shuya Zhang, Ji Young Kim, Suowen Xu, Huan Liu, Meimei Yin, Marina Koroleva, Jia Guo, Xiuying Pei, Zheng Gen Jin

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  11. Review
  12. Enhanced Sp1/YY1 Expression DirectsHypertension (Dallas, Tex. : 1979) · 2021
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shuya ZhangAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.
Ji Young KimAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.
Suowen XuAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.
Huan LiuAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.
Meimei YinAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.
Marina KorolevaAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.
Jia GuoPulmonary Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.
Xiuying PeiKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Zheng Gen JinAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; Zheng-gen_jin@urmc.rochester.edu.
University of Rochester · USNingxia Medical University · CN

Funding

SIRT6 and vascular endothelial homeostasisR01HL130167 · NHLBI · UNIVERSITY OF ROCHESTER · PI JIN, ZHENG-GEN · 2017 to 2025
$4.2M
Epigenetic regulation of vascular endothelial genes and laminar flow atheroprotectionR01HL141171 · NHLBI · UNIVERSITY OF ROCHESTER · PI JIN, ZHENG-GEN · 2019 to 2022
$1.9M
Regulation of angiogenesis by transcription factorsR01HL128363 · NHLBI · UNIVERSITY OF ROCHESTER · PI JIN, ZHENG-GEN · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL128363NHLBI NIH HHS R01 HL130167NHLBI NIH HHS R01 HL141171
6 · The paper itself

Abstract

Angiogenesis, the formation of new blood vessels, is tightly regulated by gene transcriptional programs. Yin Ying 1 (YY1) is a ubiquitously distributed transcription factor with diverse and complex biological functions; however, little is known about the cell-type-specific role of YY1 in vascular development and angiogenesis. Here we report that endothelial cell (EC)-specific

Indexed as

AnimalsCarrier ProteinsCell DifferentiationEndothelial CellsFemaleGene Expression Regulation, DevelopmentalHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinMaleMiceMice, Inbred C57BLMice, KnockoutMorphogenesisNeovascularization, PathologicNeovascularization, PhysiologicNuclear ProteinsCarrier ProteinsImmunoglobulin J Recombination Signal Sequence-Binding ProteinMaml1 protein, mouseNuclear ProteinsRBPJ protein, humanRbpj protein, mouseReceptors, NotchTranscription FactorsYY1 protein, humanYy1 protein, mouseYY1 Transcription Factorendothelial cellsRBPJsprouting angiogenesistranscription factorYY1

Identifiers

PMID32075915
PMCPMC7060702
OpenAlexW3008398806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.