ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Cortico-Thalamo-Cortical Circuits of Mouse Forelimb S1 Are Organized Primarily as Recurrent Loops.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 86 citations in OpenAlex.
- Interpretable Machine Learning Identifies an Emergent Absence Seizure Mechanism.bioRxiv : the preprint server for biology · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Modulation and Gating of Transthalamic and Subcortical Pathways through Somatosensory Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Article
- Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse's hand.eLife · 2025Article
- Connectivity of single neurons classifies cell subtypes in mouse brains.Nature methods · 2025Article
- Preconfigured cortico-thalamic neural dynamics constrain movement-associated thalamic activity.Nature communications · 2024Article
- Symmetry in Frontal But Not Motor and Somatosensory Cortical Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- Symmetry in frontal but not motor and somatosensory cortical projections.bioRxiv : the preprint server for biology · 2024Article
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease.Cellular and molecular life sciences : CMLS · 2023Article
- Neuronal Connectivity as a Determinant of Cell Types and Subtypes.Research square · 2023Article
- Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner.Nature communications · 2023Article
- Protocol for mouse optogenetic fMRI at ultrahigh magnetic fields.STAR protocols · 2022Article
- Conserved patterns of functional organization between cortex and thalamus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE.Frontiers in neuroinformatics · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cortical projections to the thalamus arise from corticothalamic (CT) neurons in layer 6 and pyramidal tract-type (PT) neurons in layer 5B. We dissected the excitatory synaptic connections in the somatosensory thalamus formed by CT and PT neurons of the primary somatosensory (S1) cortex, focusing on mouse forelimb S1. Mice of both sexes were studied. The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior lateral and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops. The PT neurons in S1 also formed a recurrent loop with S1-projecting TC neurons in the same subregion of the PO. The PT neurons in the adjacent primary motor (M1) cortex formed a separate recurrent loop with M1-projecting TC neurons in a nearby subregion of the PO. Collectively, our results reveal that C-T-C circuits of mouse forelimb S1 are primarily organized as multiple cortical cell-type-specific and thalamic subnucleus-specific recurrent loops, with both CT and PT neurons providing the strongest excitatory input to TC neurons that project back to S1. The findings, together with those of related studies of C-T-C circuits, thus suggest that recurrently projecting thalamocortical neurons are the principal targets of cortical excitatory input to the mouse somatosensory and motor thalamus.
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