Evidence map›Paper›PMID 32075887›Full record

Trial reportGut2020

Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake.

Victoria Meslier, Manolo Laiola, Henrik Munch Roager, Francesca De Filippis, Hugo Roume, Benoit Quinquis, Rosalba Giacco, Ilario Mennella, Rosalia Ferracane, Nicolas Pons and 6 more

4 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 343 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
343citing papers in PubMed, 14 pooled it
53.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05457439 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Sustainable-psycho-nutritional Intervention Program and Its Effects on Water and Carbon Footprint, Metabolic Biomarkers, and Gut Microbiota in Mexican Population: a m-Health Randomized Clinical Trial

TypeinterventionalSponsorUniversity of GuadalajaraRan2022 to 2023Enrolled112ConditionsGut Microbiota, Hyperglycemia, Hypercholesterolemia, HDLCArmsSustainable diet promotion through behavioral change intervention
NCT05575258 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Effects of Agro-ecological Farming Systems on Human Health -- A Randomized Controlled Trial of Agro-ecologically vs Conventionally Produced Foods on Human Health Biomarkers

TypeinterventionalSponsorUtah State UniversityRan2022 to 2025Enrolled34ConditionsInflammatory ResponseArms44-Day Diet Conventionally Sourced - YELLOW Diet, 44-Day Diet Agro-Ecologically Sourced - GREEN Diet
NCT05999136 nacompletednot on this mapstarted 2024, after this paper: background citation

Discovering the Effects of Pulses Through the Gut Microbiome and Bioavailability of Bioactive Compounds

TypeinterventionalSponsorPaola VitaglioneRan2024 to 2024Enrolled84ConditionsLifestyle-related ConditionArmsPulses diet, Plant proteins diet, Habitual diet
NCT07007169 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Mediterranean Diet and Inequality in Early Breast Cancer: A Multicenter Randomized Clinical Trial

TypeinterventionalSponsorEsbjerg Hospital - University Hospital of Southern DenmarkRan2025 to 2036Enrolled105ConditionsEarly Breast CancerArmsThe goal is daily consumption of a minimum of 30 grams of dietary fiber and weekly consumption of a minimum of 30 different plant foods, minimizing the amount of ultra-processed food., Standard Diet
3 · Its place in the literature

Who cites it

343 citing papers in PubMed, 14 syntheses or guidelines pooled it, 551 citations in OpenAlex.

  1. Pooled it
  2. Altered molecular signature of the intestinal microbiota in irritable bowel syndrome patients versus healthy controls: An updated systematic review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

283 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Victoria Meslier *Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Manolo Laiola *Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Henrik Munch Roager *Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0002-2504-8313
Francesca De FilippisDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Hugo RoumeUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Benoit QuinquisUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Rosalba GiaccoInstitute of Food Science of CNR, Avellino, Italy.
Ilario MennellaDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Rosalia FerracaneDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Nicolas PonsUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.
Edoardo PasolliDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Angela RivelleseTask Force on Microbiome Studies, University of Naples Federico II, Naples, Italy.
Lars Ove DragstedDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0003-0609-6317
Paola VitaglioneDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy ercolini@unina.it stanislav.ehrlich@inra.fr paola.vitaglione@unina.it.
Stanislav Dusko EhrlichUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France ercolini@unina.it stanislav.ehrlich@inra.fr paola.vitaglione@unina.it.ORCID 0000-0002-7563-4046
Danilo ErcoliniDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy ercolini@unina.it stanislav.ehrlich@inra.fr paola.vitaglione@unina.it.ORCID 0000-0003-3061-9560
Federico II University Hospital · ITUniversité Paris-Saclay · FRUniversity of Copenhagen · DKInstitute of Food Science · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to explore the effects of an isocaloric Mediterranean diet (MD) intervention on metabolic health, gut microbiome and systemic metabolome in subjects with lifestyle risk factors for metabolic disease.

designEighty-two healthy overweight and obese subjects with a habitually low intake of fruit and vegetables and a sedentary lifestyle participated in a parallel 8-week randomised controlled trial. Forty-three participants consumed an MD tailored to their habitual energy intakes (MedD), and 39 maintained their regular diets (ConD). Dietary adherence, metabolic parameters, gut microbiome and systemic metabolome were monitored over the study period.

resultsIncreased MD adherence in the MedD group successfully reprogrammed subjects' intake of fibre and animal proteins. Compliance was confirmed by lowered levels of carnitine in plasma and urine. Significant reductions in plasma cholesterol (primary outcome) and faecal bile acids occurred in the MedD compared with the ConD group. Shotgun metagenomics showed gut microbiome changes that reflected individual MD adherence and increase in gene richness in participants who reduced systemic inflammation over the intervention. The MD intervention led to increased levels of the fibre-degrading

conclusionSwitching subjects to an MD while maintaining their energy intake reduced their blood cholesterol and caused multiple changes in their microbiome and metabolome that are relevant in future strategies for the improvement of metabolic health.

Indexed as

Diet, MediterraneanGastrointestinal MicrobiomeMetabolomeAdultCholesterolEnergy IntakeFemaleHumansMaleObesityOverweightCholesteroldietintestinal microbiologynutrition

Identifiers

PMID32075887
PMCPMC7306983
OpenAlexW3007138124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.