ArticleOccupational and environmental medicine2020
Association between occupational solvent exposure and cognitive performance in the French CONSTANCES study.
Article in Occupational and environmental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- CONSTANCES, the French nationwide population cohort: major accomplishments.European journal of epidemiology · 2026Article
- Multidimensional workplace stressors differentially impact cognitive trajectories.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Chronic lymphatic leukaemia in a worker with a long-term occupational exposure to petroleum product mixtures: a case report.Arhiv za higijenu rada i toksikologiju · 2026Article
- Environmental toxins in neurodegeneration - a narrative review.Neurological research and practice · 2025Review
- Article
- Assessing the contribution of the chemical exposome to neurodegenerative disease.Nature neuroscience · 2024Article
- Successful prevention of organic solvent induced disorders: history and lessons.Scandinavian journal of work, environment & health · 2024Article
- Article
- Case Report: Toxic encephalopathy caused by repeated inhalation of liquid sealant.Frontiers in public health · 2022Article
- Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to evaluate the association between occupational exposure to solvents and cognitive performance in middle-aged and early-ageing participants, taking into account the working environment.
methodsIn the French Cohorte des consultants des Centres d'examens de santé (CONSTANCES) cohort, 41 854 participants aged 45-
resultsMen had a greater risk of global cognitive impairment when they were exposed to gasoline (relative risk (RR)=1.12, 95% CI 1.03 to 1.22), white spirit (RR=1.14, 95% CI 1.05 to 1.25) or cellulosic thinner (RR=1.17, 95% CI 1.06 to 1.31) at the workplace, even after adjusting for confounders. Women exposed to white spirit or exposed for more than 20 years had poorer global cognitive performance.
conclusionThese findings strengthen our understanding of the detrimental effect of solvent exposure on cognitive health not only in men but also in women for the first time, in a large general population middle-aged and early-ageing sample from France, taking into account working conditions.
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Registered trials
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