ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2020
Alcohol sensitivity in women after undergoing bariatric surgery: a cross-sectional study.
Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02766322 (Pharmacokinetics and Subjective Responses to Alcohol After Bariatric Surgery), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacokinetics and Subjective Responses to Alcohol After Bariatric Surgery
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Alcohol Misuse post Metabolic and Bariatric Surgery: A Systematic Review of Longer-term Studies with Focus on new Onset Alcohol use Disorder and Differences Between Surgery Types.Current obesity reports · 2024Pooled it
- Alcohol and Substance Use After Bariatric Surgery: Nutritional Risks and Clinical Implications in Long-Term Postoperative Care.Nutrients · 2026Review
- Crosstalk between alcohol use disorder and obesity: two sides of the same coin?Molecular psychiatry · 2025Review
- Increased alcohol intake and alcohol use disorder following bariatric surgery: potential mechanisms.Physiology & behavior · 2025Review
- Psychological and psychiatric standardized procedures for metabolic bariatric surgery: a clinical practice model for mental health providers.Updates in surgery · 2025Review
- Recent advances in alcohol metabolism: from the gut to the brain.Physiological reviews · 2025Review
- Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice.Alcohol, clinical & experimental research · 2025Article
- Bariatric surgery and alcohol and substance use: A case-control survey study.Drug and alcohol dependence · 2025Article
- ALCOHOL USE DISORDER AND DEPRESSION IN PATIENTS AFTER UNDERGOING BARIATRIC SURGERY.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2025Article
- Glucagon-like peptide-1, fibroblast growth factor 21, and other endocrine responses to alcohol ingestion in women before and after metabolic surgery.Frontiers in pharmacology · 2025Article
- The glucagon-like peptide-1 and other endocrine responses to alcohol ingestion in women with versus without metabolic surgery.Addiction biology · 2024Article
- Alcohol associated liver disease and bariatric surgery: Current perspectives and future directions.World journal of gastrointestinal surgery · 2024Review
- Vagus nerve damage increases alcohol intake and preference in a nonpreferring rat line: Relationship to vagal regulation of the hypothalamic-pituitary-adrenal axis.Alcohol, clinical & experimental research · 2024Article
- Food and alcohol disturbance among people who have undergone bariatric surgery.Obesity science & practice · 2024Article
- Bariatric surgery patients in AUD treatment in Norway-an exploratory cross-sectional study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Observational
- Response to commentary on: "Fat-free mass accounts for most of the variance in alcohol elimination rate in women".Alcohol, clinical & experimental research · 2023Article
- Article
- Fat-free mass accounts for most of the variance in alcohol elimination rate in women.Alcohol, clinical & experimental research · 2023Article
- Bariatric Surgery Is Associated with Alcohol-Related Liver Disease and Psychiatric Disorders Associated with AUD.Obesity surgery · 2023Article
- Patient perceptions regarding alcohol use after bariatric surgery.Surgical endoscopy · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundRoux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the most common bariatric surgeries performed worldwide, increase the risk to develop an alcohol use disorder. This might be due, in part, to surgery-related changes in alcohol pharmacokinetics. Another risk factor, unexplored within this population, is having a reduced subjective response to alcohol's sedative effects.
objectivesTo assess whether the alcohol sensitivity questionnaire (ASQ), a simple self-report measure, could pinpoint reduced alcohol sensitivity in the bariatric population.
settingUniversity medical centers in Missouri and Illinois.
methodsWomen who had RYGB (n = 16), SG (n = 28), or laparoscopic adjustable gastric banding surgery (n = 11) within the last 5 years completed the ASQ for both pre- and postsurgical timeframes, and 45 of them participated in oral alcohol challenge testing postsurgery. Blood alcohol concentration (BAC) and subjective stimulation and sedation were measured before and for 3.5 hours after drinking.
resultsIn line with faster and higher peak BACs after RYGB and SG than laparoscopic adjustable gastric banding surgery (P < .001), postsurgery ASQ scores were more reduced from presurgery scores after RYGB/SG than after laparoscopic adjustable gastric banding surgery (-2.3 ± .3 versus -1.2 ± .2; P < .05). However, despite the dramatic changes in BAC observed when ingesting alcohol after RYGB/SG surgeries, which resulted in peak BAC that were approximately 50% above the legal driving limit, a third of these women felt almost no alcohol-related sedative effects.
conclusionsAlthough RYGB/SG dramatically increased sensitivity to alcohol in all participants, meaningful interindividual differences remained. The ASQ might help identify patients at increased risk to develop an alcohol use disorder after surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.