Evidence map›Paper›PMID 32075624›Full record

SynthesisBMC oral health2020

Non-significant association between - 330 T/G polymorphism in interleukin-2 gene and chronic periodontitis: findings from a meta-analysis.

Felipe Rodolfo Pereira da Silva, Juliana Gomes Galeno, Alessandro Luiz Araújo Bentes Leal, Reyce Santos Koga, Nayana Yared Batista, Silvânia da Conceição Furtado, Daniel Fernando Pereira Vasconcelos, Marcelo Diniz Carvalho, José Fernando Marques Barcellos

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Association between IL-1 Gene Polymorphisms and Stage III Grade B Periodontitis in Polish Population.International journal of environmental research and public health · 2022
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Felipe Rodolfo Pereira da SilvaDoctorate Post-Graduation Program in Basic and Applied Immunology, Federal University of Amazonas, Manaus, Amazonas, Brazil. feliperodolfo.15@hotmail.com.ORCID 0000-0001-9224-5571
Juliana Gomes GalenoLaboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil.
Alessandro Luiz Araújo Bentes LealDepartment of Morphology, Federal University of Amazonas, General Rodrigo Octavio Jordão Ramos Avenue, 1200, Coroado, Manaus, Amazonas, CEP: 69067-005, Brazil.
Reyce Santos KogaDepartment of Morphology, Federal University of Amazonas, General Rodrigo Octavio Jordão Ramos Avenue, 1200, Coroado, Manaus, Amazonas, CEP: 69067-005, Brazil.
Nayana Yared BatistaDoctorate Post-Graduation Program in Basic and Applied Immunology, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Silvânia da Conceição FurtadoDepartment of Morphology, Federal University of Amazonas, General Rodrigo Octavio Jordão Ramos Avenue, 1200, Coroado, Manaus, Amazonas, CEP: 69067-005, Brazil.
Daniel Fernando Pereira VasconcelosLaboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil.
Marcelo Diniz CarvalhoDepartment of Periodontology, Amazonas State University, Manaus, Amazonas, Brazil.
José Fernando Marques BarcellosDoctorate Post-Graduation Program in Basic and Applied Immunology, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Universidade Federal do Amazonas · BRUniversidade Federal do Piauí · BRUniversidade do Estado do Amazonas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 gene may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data.

methodsA literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I

resultsFive studies were identified in diverse ethnical groups with 1425 participants. The - 330 T/G polymorphism in IL2 gene was not significantly associated with CP in allelic evaluation (P > 0.05) as well as in the genotypic comparisons (P = 0.15). The Begg's test and the linear regression Egger's test did not show any evidence of publication bias risk (P > 0.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic.

conclusionsThis meta-analysis showed a non-significant association between - 330 T/G polymorphism in IL2 gene and CP in any allelic evaluation.

Indexed as

AllelesChronic PeriodontitisGenetic Predisposition to DiseaseHumansInterleukin-2Polymorphism, GeneticPolymorphism, Single NucleotideRisk FactorsInterleukin-2AlleleCytokineOdds ratioPeriodontal diseaseRisk factor

Identifiers

PMID32075624
PMCPMC7031920
OpenAlexW3009951219

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.