Evidence map›Paper›PMID 32075515›Full record

ReviewAnnual review of physical chemistry2020

The Maximum Caliber Variational Principle for Nonequilibria.

Kingshuk Ghosh, Purushottam D Dixit, Luca Agozzino, Ken A Dill

Abstract readReview
In one paragraph

Review in Annual review of physical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. The Trajectory Statistics of Biological Exploratory Dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Modeling and inferring metacommunity dynamics with Maximum Caliber.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Generative AI for computational chemistry: A roadmap to predicting emergent phenomena.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Tutorial on integrative spatiotemporal modeling by integrative modeling platform.Protein science : a publication of the Protein Society · 2025
    Article
  6. Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  14. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kingshuk GhoshDepartment of Physics and Astronomy, University of Denver, Denver, Colorado 80209, USA; email: kghosh@du.edu.
Purushottam D DixitDepartment of Systems Biology, Columbia University, New York, NY 10032, USA.
Luca AgozzinoLaufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794, USA; email: dill@laufercenter.org.
Ken A DillLaufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794, USA; email: dill@laufercenter.org.

Funding

Quantifying fluctuations to buildpredictive models and guide design of gene networksR15GM128162 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GHOSH, KINGSHUK · 2018 to 2018
$367k
NIGMS NIH HHS R15 GM128162
6 · The paper itself

Abstract

Ever since Clausius in 1865 and Boltzmann in 1877, the concepts of entropy and of its maximization have been the foundations for predicting how material equilibria derive from microscopic properties. But, despite much work, there has been no equally satisfactory general variational principle for nonequilibrium situations. However, in 1980, a new avenue was opened by E.T. Jaynes and by Shore and Johnson. We review here maximum caliber, which is a maximum-entropy-like principle that can infer distributions of flows over pathways, given dynamical constraints. This approach is providing new insights, particularly into few-particle complex systems, such as gene circuits, protein conformational reaction coordinates, network traffic, bird flocking, cell motility, and neuronal firing.

Indexed as

Gene Regulatory NetworksModels, TheoreticalDNAEntropyKineticsModels, ChemicalModels, GeneticMolecular Dynamics SimulationNucleic Acid ConformationProtein ConformationProteinsDNAProteinsbiological dynamicscaliberentropyinferencenetwork modelsnonequilibriumvariational principles

Identifiers

PMID32075515
PMCPMC9827727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.