Evidence map›Paper›PMID 32075290›Full record

ArticleInternational journal of molecular sciences2020

In Vivo and In Vitro Mechanical Loading of Mouse Achilles Tendons and Tenocytes-A Pilot Study.

Viviane Fleischhacker, Franka Klatte-Schulz, Susann Minkwitz, Aysha Schmock, Maximilian Rummler, Anne Seliger, Bettina M Willie, Britt Wildemann

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Animal model for tendinopathy.Journal of orthopaedic translation · 2023
    Review
  8. Review
  9. The tendon unit: biochemical, biomechanical, hormonal influences.Journal of orthopaedic surgery and research · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Dynamic Load Model Systems of Tendon Inflammation and Mechanobiology.Frontiers in bioengineering and biotechnology · 2022
    Review
  14. Article
  15. Article
  16. Identification and Distinction of Tenocytes and Tendon-Derived Stem Cells.Frontiers in cell and developmental biology · 2021
    Review
  17. Growth Factor Roles in Soft Tissue Physiology and Pathophysiology.Advances in experimental medicine and biology · 2021
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Viviane FleischhackerDepartment of Trauma-, Hand- and Reconstructive Surgery, Experimental Trauma Surgery, University Hospital Jena, 07743 Jena, Germany.
Franka Klatte-SchulzJulius Wolff Institute, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.ORCID 0000-0001-6079-228X
Susann MinkwitzJulius Wolff Institute, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.
Aysha SchmockJulius Wolff Institute, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.
Maximilian RummlerResearch Centre, Shriners Hospital for Children-Canada, Department of Pediatric Surgery, McGill University, Montreal, QC H3A 0G4, Canada.
Anne SeligerJulius Wolff Institute, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.
Bettina M WillieResearch Centre, Shriners Hospital for Children-Canada, Department of Pediatric Surgery, McGill University, Montreal, QC H3A 0G4, Canada.
Britt WildemannDepartment of Trauma-, Hand- and Reconstructive Surgery, Experimental Trauma Surgery, University Hospital Jena, 07743 Jena, Germany.ORCID 0000-0002-8365-1188
Humboldt-Universität zu Berlin · DEMcGill University · CAJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical force is a key factor for the maintenance, adaptation, and function of tendons. Investigating the impact of mechanical loading in tenocytes and tendons might provide important information on in vivo tendon mechanobiology. Therefore, the study aimed at understanding if an in vitro loading set up of tenocytes leads to similar regulations of cell shape and gene expression, as loading of the Achilles tendon in an in vivo mouse model. In vivo: The left tibiae of mice (

Indexed as

Stress, MechanicalAchilles TendonAnimalsBiomechanical PhenomenaCell ShapeCollagen Type IExtracellular MatrixGene Expression RegulationHumansMatrix MetalloproteinasesMicePilot ProjectsTendinopathyTendon InjuriesTenocytesWeight-BearingCollagen Type IMatrix Metalloproteinasescell cultureextracellular matrixmechanical loadingtendon

Identifiers

PMID32075290
PMCPMC7072865
OpenAlexW3005611960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.