Evidence map›Paper›PMID 32075097›Full record

ArticleCells2020

Concetta D'Ambrosio, Jessica Erriquez, Maddalena Arigoni, Sonia Capellero, Gloria Mittica, Eleonora Ghisoni, Fulvio Borella, Dionyssios Katsaros, Silvana Privitera, Marisa Ribotta and 14 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. High Frequency ofCancers · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Artificial Intelligence-Assisted Serial Analysis of Clinical Cancer Genomics Data Identifies Changing Treatment Recommendations and Therapeutic Targets.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 2 countries.

Concetta D'AmbrosioCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Jessica ErriquezCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Maddalena ArigoniDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.
Sonia CapelleroCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Gloria MitticaCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Eleonora GhisoniCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Fulvio BorellaCittà della Salute e della Scienza, 10126 Torino, Italy.
Dionyssios KatsarosCittà della Salute e della Scienza, 10126 Torino, Italy.
Silvana PriviteraCittà della Salute e della Scienza, 10126 Torino, Italy.
Marisa RibottaCittà della Salute e della Scienza, 10126 Torino, Italy.
Elena MaldiCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Giovanna Di NardoDepartment of Life Sciences and Systems Biology, University of Torino, 10125 Torino, Italy.
Enrico BerrinoCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Tiziana VenesioCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Riccardo PonzoneCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Marco VairaCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Douglas HallUniversity of Cambridge, Cambridge CB2 0XZ, UK.
Mercedes Jimenez-LinanUniversity of Cambridge, Cambridge CB2 0XZ, UK.
Anna L PatersonUniversity of Cambridge, Cambridge CB2 0XZ, UK.
Raffaele A CalogeroDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.
James D BrentonUniversity of Cambridge, Cambridge CB2 0XZ, UK.
Giorgio ValabregaCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Maria Flavia Di RenzoCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Martina OliveroCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Candiolo Cancer Institute · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITUniversity of Cambridge · GBUniversity of Turin · IT

Funding

Cancer Research UK 22905Cancer Research UK A15601
6 · The paper itself

Abstract

Identifying cancer drivers and actionable mutations is critical for precision oncology. In epithelial ovarian cancer (EOC) the majority of mutations lack biological or clinical validation. We fully characterized 43 lines of Patient-Derived Xenografts (PDXs) and performed copy number analysis and whole exome sequencing of 12 lines derived from naïve, high grade EOCs. Pyrosequencing allowed quantifying mutations in the source tumours. Drug response was assayed on PDX Derived Tumour Cells (PDTCs) and in vivo on PDXs. We identified a

Indexed as

AnimalsCarcinoma, Ovarian EpithelialCell Line, TumorClass Ia Phosphatidylinositol 3-KinaseCystadenocarcinoma, SerousFemaleHeterograftsHumansMiceMice, Inbred NODMice, SCIDMolecular Targeted TherapyMutationNeoplasm GradingOvarian NeoplasmsRandom AllocationClass Ia Phosphatidylinositol 3-KinasePIK3R1 protein, humanovarian cancerPatient-Derived xenograftsPDX derived tumour cellsPI3KPIK3R1

Identifiers

PMID32075097
PMCPMC7072782
OpenAlexW3005921366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.