Evidence map›Paper›PMID 32075053›Full record

ArticleInternational journal of molecular sciences2020

Genetic Variants Detected Using Cell-Free DNA from Blood and Tumor Samples in Patients with Inflammatory Breast Cancer.

Jennifer S Winn, Zachary Hasse, Michael Slifker, Jianming Pei, Sebastian M Arisi-Fernandez, Jacqueline N Talarchek, Elias Obeid, Donald A Baldwin, Yulan Gong, Eric Ross and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jennifer S WinnFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Zachary HasseFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Michael SlifkerFox Chase Cancer Center, Philadelphia, PA 19111, USA.ORCID 0000-0002-9718-5966
Jianming PeiFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Sebastian M Arisi-FernandezFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Jacqueline N TalarchekFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Elias ObeidFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Donald A BaldwinFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Yulan GongFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Eric RossFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Massimo CristofanilliFox Chase Cancer Center, Philadelphia, PA 19111, USA.
R Katherine AlpaughFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Sandra V FernandezFox Chase Cancer Center, Philadelphia, PA 19111, USA.ORCID 0000-0002-5859-963X
Fox Chase Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
NCI NIH HHS P30 CA006927
6 · The paper itself

Abstract

We studied genomic alterations in 19 inflammatory breast cancer (IBC) patients with advanced disease using samples of tissue and paired blood serum or plasma (cell-free DNA, cfDNA) by targeted next generation sequencing (NGS). At diagnosis, the disease was triple negative (TN) in eleven patients (57.8%), ER+ Her2- IBC in six patients (31.6%), ER+ Her2+ IBC in one patient (5.3%), and ER- Her2+ IBC in one other patient (5.3%). Pathogenic or likely pathogenic variants were frequently detected in

Indexed as

Genetic VariationAdultAgedAllelesBRCA2 ProteinBreast NeoplasmsCell-Free Nucleic AcidsFemaleGene FrequencyHigh-Throughput Nucleotide SequencingHumansMiddle AgedMismatch Repair Endonuclease PMS2Neoplasm StagingTumor Suppressor Protein p53BRCA2 ProteinBRCA2 protein, humanCell-Free Nucleic AcidsMismatch Repair Endonuclease PMS2PMS2 protein, humanTP53 protein, humanTumor Suppressor Protein p53cell-free DNA (cfDNA)inflammatory breast cancer (IBC)next generation sequencing (NGS)

Identifiers

PMID32075053
PMCPMC7072950
OpenAlexW3006344526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.