Evidence map›Paper›PMID 32075046›Full record

ReviewBiomolecules2020

Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular Carcinoma.

Jian Wang, Cun-Di Li, Lin Sun

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

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  17. CD96 as a Potential Immune Regulator in Cancers.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jian WangDepartment of Aetiology and Immunology, Medical College, Anhui University of Science & Technology, Huainan 232001, Anhui, China.
Cun-Di LiDepartment of Aetiology and Immunology, Medical College, Anhui University of Science & Technology, Huainan 232001, Anhui, China.
Lin SunDepartment of Aetiology and Immunology, Medical College, Anhui University of Science & Technology, Huainan 232001, Anhui, China.
Anhui University of Science and Technology · CN

Funding

Educational Science Foundation of Anhui Province, China KJ2016SD20, 2015zdjy068Science Foundation of Anhui Province, China 1308085MH148Science Projects of China Coal Industry Association MTKJ 2015-333 and MTKJ 2015-332
6 · The paper itself

Abstract

Hepatocellular carcinoma is a common malignant tumor with high mortality. Its malignant proliferation, invasion, and metastasis are closely related to the cellular immune function of the patients. NKG2D is a key activated and type II membrane protein molecule expressed on the surface of almost all NK cells. The human NKG2D gene is 270 kb long, located at 12p12.3-p13.1, and contains 10 exons and 9 introns. The three-dimensional structure of the NKG2D monomeric protein contains two alpha-helices, two beta-lamellae, and four disulfide bonds, and its' signal of activation is transmitted mainly by the adaptor protein (DAP). NKG2D ligands, including MICA, MICB, and ULBPs, can be widely expressed in hepatoma cells. After a combination of NKG2D and DAP10 in the form of homologous two polymers, the YxxM motif in the cytoplasm is phosphorylated and then signaling pathways are also gradually activated, such as PI3K, PLCγ2, JNK-cJunN, and others. Activated NK cells can enhance the sensitivity to hepatoma cells and specifically dissolve by releasing a variety of cytokines (TNF-α and IFN-γ), perforin, and high expression of FasL, CD16, and TRAIL. NK cells may specifically bind to the over-expressed MICA, MICB, and ULBPs of hepatocellular carcinoma cells through the surface activating receptor NKG2D, which can help to accurately identify hepatoma, play a critical role in anti-hepatoma via the pathway of cytotoxic effects, and obviously delay the poor progress of hepatocellular carcinoma.

Indexed as

Adaptor Proteins, Signal TransducingCarcinoma, HepatocellularCytokinesHumansKiller Cells, NaturalLigandsLiver NeoplasmsNK Cell Lectin-Like Receptor Subfamily KSignal TransductionAdaptor Proteins, Signal TransducingCytokinesKLRK1 protein, humanLigandsNK Cell Lectin-Like Receptor Subfamily Kcytokineshepatocellular carcinomaligandNKG2Doncolytic effectperforinsignal transduction

Identifiers

PMID32075046
PMCPMC7094213
OpenAlexW3005702277

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.