Evidence map›Paper›PMID 32074951›Full record

ArticleMolecules (Basel, Switzerland)2020

Encapsulation of Variabilin in Stearic Acid Solid Lipid Nanoparticles Enhances Its Anticancer Activity in Vitro.

Mookho S Lerata, Sarah D'Souza, Nicole R S Sibuyi, Admire Dube, Mervin Meyer, Toufiek Samaai, Edith M Antunes, Denzil R Beukes

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Metabolomic and Pharmacological Approaches for Exploring the Potential ofInternational journal of molecular sciences · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Emerging Roles of Ceramides in Breast Cancer Biology and Therapy.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mookho S LerataSchool of Pharmacy, University of the Western Cape, Bellville 7535, South Africa.
Sarah D'SouzaSchool of Pharmacy, University of the Western Cape, Bellville 7535, South Africa.
Nicole R S SibuyiDepartment of Science and Technology/Mintek Nanotechnology Innovation Centre (DST/Mintek NIC), Biolabels Node, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.
Admire DubeSchool of Pharmacy, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0001-7175-5388
Mervin MeyerDepartment of Science and Technology/Mintek Nanotechnology Innovation Centre (DST/Mintek NIC), Biolabels Node, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-5684-6094
Toufiek SamaaiDepartment of Environmental Affairs, Oceans and Coasts Research Chief Directorate, Marine Biodiversity and Ecosystems Research, Victoria & Alfred Waterfront, P.O. Box 52126, Cape Town 8000, South Africa.
Edith M AntunesDepartment of Chemistry, University of the Western Cape, Bellville 7535, South Africa.
Denzil R BeukesSchool of Pharmacy, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-7303-0863

Funding

National Research Foundation South Africa 93639
6 · The paper itself

Abstract

The use of natural products as chemotherapeutic agents is well established; however, many of these are associated with undesirable side effects, including high toxicity and instability. Furthermore, the development of drug resistant cancers makes the search for new anticancer lead compounds a priority. In this study, the extraction of an

Indexed as

Antineoplastic AgentsBreast NeoplasmsCell ProliferationCell SurvivalFemaleHumansLipidsMCF-7 CellsNanoparticlesProteinsStearic AcidsAntineoplastic AgentsLipidsProteinsstearic acidStearic Acidsvariabilinanti-cancer activityIrcinia sp.marine natural productssolid lipid nanoparticlesspongevariabilin

Identifiers

PMID32074951
PMCPMC7070932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.