Evidence map›Paper›PMID 32074512›Full record

ArticleJournal of neural engineering2020

Twister3: a simple and fast microwire twister.

Jonathan P Newman, Jakob Voigts, Maxim Borius, Mattias Karlsson, Mark T Harnett, Matthew A Wilson

Abstract read
In one paragraph

Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan P NewmanDepartment of Brain and Cognitive Sciences, MIT, Cambridge, MA, United States of America.ORCID 0000-0002-5425-3340
Jakob VoigtsDepartment of Brain and Cognitive Sciences, MIT, Cambridge, MA, United States of America.ORCID 0000-0002-5174-7214
Maxim BoriusSpikeGadgets LLC, San Francisco, CA, United States of America.
Mattias KarlssonSpikeGadgets LLC, San Francisco, CA, United States of America.
Mark T HarnettDepartment of Brain and Cognitive Sciences, MIT, Cambridge, MA, United States of America.
Matthew A WilsonDepartment of Brain and Cognitive Sciences, MIT, Cambridge, MA, United States of America.

Funding

Dendritic Computation and Representation of Head Direction in Retrosplenial CortexR01NS113079 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HARNETT, MARK THOMAS · 2019 to 2023
$2.2M
A dendritic mechanism for cholinergic neuromodulation of cortical functionR01NS106031 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HARNETT, MARK THOMAS · 2018 to 2022
$1.7M
Revealing the causal role of hippocampal dopamine signaling in spatial learningF32MH107086 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NEWMAN, JONATHAN · 2015 to 2017
$168k
NIMH NIH HHS F32 MH107086NINDS NIH HHS R01 NS106031NINDS NIH HHS R01 NS113079
6 · The paper itself

Abstract

objectiveTwisted wire probes (TWPs, e.g. stereotrodes and tetrodes) provide a cheap and reliable method for obtaining high quality, multiple single-unit neural recordings in freely moving animals. Despite their ubiquity, TWPs are constructed using a tedious procedure consisting of manually folding, turning, and fusing microwire. This imposes a significant labor burden on research personnel who use TWPs in their experiments. APPROACH: To address this issue, we created Twister3, an open-source microwire twisting machine. This machine features a quick-draw wire feeder that eliminates manual wire folding, an auto-aligning motor attachment mechanism which results in consistently straight probes, and a high speed motor for rapid probe turning. MAIN

resultsTwister3 greatly increases the speed and repeatability of constructing twisted microwire probes compared to existing options. Users with less than one hour of experience using the device were able to make ~70 tetrodes per hour, on average. It is cheap, well documented, and all associated designs and source code are open-source. SIGNIFICANCE: Twister3 significantly reduces the labor burden of creating high-quality TWPs so electrophysiologists can spend more of their time performing recordings rather than making probes. Therefore, this device is of interest to any lab performing TWP neural recordings, for example, using microdrives.

Indexed as

Electrodes, ImplantedAnimals

Identifiers

PMID32074512
PMCPMC8879418

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.