Evidence map›Paper›PMID 32074468›Full record

ArticleJournal of women's health (2002)2020

Microvascular Disease and Small-Vessel Disease: The Nexus of Multiple Diseases of Women.

Hena Patel, Neelum T Aggarwal, Anupama Rao, Elizabeth Bryant, Rupa M Sanghani, Mary Byrnes, Dinesh Kalra, Leigh Dairaghi, Lynne Braun, Sherine Gabriel and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of women's health (2002), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Sex-Based Differences in Long-Term Outcomes Following Intravascular Brachytherapy for In-Stent Restenosis.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Impact of Estrogen on Purinergic Signaling in Microvascular Disease.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  17. Article
  18. Observational
  19. Article
  20. Peripheral arterial disease: A small and large vessel problem.American heart journal plus : cardiology research and practice · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hena PatelDepartment of Cardiology, Rush Medical College, Rush University, Chicago, Illinois.
Neelum T AggarwalDepartment of Neurological Sciences, Rush Alzheimer's Disease Center, Rush Medical College, Rush University, Chicago, Illinois.
Anupama RaoDepartment of Cardiology, Rush Medical College, Rush University, Chicago, Illinois.
Elizabeth BryantRush Medical College, Rush University, Chicago, Illinois.
Rupa M SanghaniDepartment of Cardiology, Rush Medical College, Rush University, Chicago, Illinois.
Mary ByrnesClinical Nursing, Rush Medical College, Rush University, Chicago, Illinois.
Dinesh KalraDepartment of Cardiology, Rush Medical College, Rush University, Chicago, Illinois.
Leigh DairaghiRush Medical College, Rush University, Chicago, Illinois.
Lynne BraunRush College of Nursing and Medicine, Rush University, Chicago, Illinois.
Sherine GabrielDepartment of Rheumatology, Rush Medical College, Rush University, Chicago, Illinois.
Annabelle Santos VolgmanDepartment of Cardiology, Rush Medical College, Rush University, Chicago, Illinois.
Rush University Medical Center · USRush University · US

Funding

MULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5M
NHLBI NIH HHS T32 HL007381
6 · The paper itself

Abstract

Microvascular disease, or small-vessel disease, is a multisystem disorder with a common pathophysiological basis that differentially affects various organs in some patients. The prevalence of small-vessel disease in the heart has been found to be higher in women compared with men. Additionally, other diseases prominently affecting women, including heart failure with preserved ejection fraction, Takotsubo cardiomyopathy, cerebral small-vessel disease, preeclampsia, pulmonary arterial hypertension (PAH), endothelial dysfunction in diabetes, diabetic cardiomyopathy, rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, may have a common etiologic linkage related to microvascular disease. To the best of our knowledge this is the first article to investigate this potential linkage. We sought to identify various diseases with a shared pathophysiology involving microvascular/endothelial dysfunction that primarily affect women, and their potential implications for disease management. Advanced imaging technologies, such as magnetic resonance imaging and positron-emission tomography, enable the detection and increased understanding of microvascular dysfunction in various diseases. Therapies that improve endothelial function, such as those used in PAH, may also be associated with benefits across the full spectrum of microvascular dysfunction. A shared pathology across multiple organ systems highlights the need for a collaborative, multidisciplinary approach among medical subspecialty practitioners who care for women with small-vessel disease. Such an approach may lead to accelerated research in diseases that affect women and their quality of life.

Indexed as

Coronary Artery DiseaseCoronary CirculationDiabetes MellitusEndotheliumFemaleHeart FailureHumansLupus Erythematosus, SystemicQuality of LifeRisk FactorsVascular Diseasescardiovascular diseasecoronary perfusion reservemicrovascular diseasemicrovascular dysfunctionsmall-vessel diseasewomen

Identifiers

PMID32074468
PMCPMC7307673
OpenAlexW3008292989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.