Evidence map›Paper›PMID 32074348›Full record

ArticleMilitary medicine2020

Initial Biphasic Fractional Anisotropy Response to Blast-Induced Mild Traumatic Brain Injury in a Mouse Model.

Palamadai N Venkatasubramanian, Juan C Pina-Crespo, Kiran Mathews, Paul H Rigby, Matthew Smith, Josh L Duckworth, Alice M Wyrwicz, Joachim Spiess

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Military medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Palamadai N VenkatasubramanianNorthshore University Health System, 1001 University Place, Evanston, IL 60201.
Juan C Pina-CrespoSanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla, CA 92037.
Kiran MathewsL3 Applied Technologies, 10180 Barnes Canyon Rd, San Diego, CA 92121.
Paul H RigbyL3 Applied Technologies, 10180 Barnes Canyon Rd, San Diego, CA 92121.
Matthew SmithNorthshore University Health System, 1001 University Place, Evanston, IL 60201.
Josh L DuckworthUniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814.
Alice M WyrwiczNorthshore University Health System, 1001 University Place, Evanston, IL 60201.
Joachim SpiessSanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla, CA 92037.
NorthShore University HealthSystem · USApplied Technologies (United States) · USDiscovery Institute · USSanford Burnham Prebys Medical Discovery Institute · USUniformed Services University of the Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBlast-induced mild traumatic brain injury was generated in a mouse model using a shock tube to investigate recovery and axonal injury from single blast.

methodsA supersonic helium wave hit the head of anesthetized male young adult mice with a reflected pressure of 69 psi for 0.2 ms on Day 1. Subsequently, the mice were cardioperfused on Days 2, 5, or 12. The isolated brains were subjected to diffusion tensor imaging. Reduced fractional anisotropy (FA) indicated axonal injury.

resultsAfter single blast, FA showed a biphasic response in the corpus callosum with decrease on Days 2 and 12 and increase on Day 5.

conclusionsBlast-induced mild traumatic brain injury in a mouse model follows a biphasic FA response within 12 days after a single blast similar to that reported for human subjects.

Indexed as

AnisotropyAnimalsBlast InjuriesBrain ConcussionDiffusion Tensor ImagingDisease Models, AnimalExplosionsMice

Identifiers

PMID32074348
PMCPMC7029837
OpenAlexW3007590112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.