ArticlePloS one2020
Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Global and regional incidence of intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis.BMC medicine · 2025Pooled it
- Pooled it
- Predictive value of fasting bile acids and liver enzymes for perinatal outcomes in intrahepatic cholestasis of pregnancy.Turkish journal of obstetrics and gynecology · 2026Article
- Association of albumin-based inflammatory indices with adverse neonatal outcomes in intrahepatic cholestasis of pregnancy: a retrospective comparative study.BMC pregnancy and childbirth · 2026Article
- The Latest on Intrahepatic Cholestasis of Pregnancy - Update 2026.Geburtshilfe und Frauenheilkunde · 2026Article
- The Relationship Between Maternal Serum Afamin Levels and Intrahepatic Cholestasis of Pregnancy and Neonatal Outcomes.Journal of clinical medicine · 2026Article
- Impact of intrahepatic cholestasis of pregnancy on neonatal respiratory outcomes (CHOLE-RESP): protocol for a prospective cohort study.Frontiers in pediatrics · 2026Article
- Total bile acid concentrations and adverse perinatal outcomes in chinese intrahepatic cholestasis of pregnancy including asymptomatic hypercholanemia of pregnancy: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Comparative analysis of vitamin K levels in women with intrahepatic cholestasis of pregnancy.BMC pregnancy and childbirth · 2025Article
- Role of aspartate aminotransferase to platelet ratio in prediction of intrahepatic cholestasis of pregnancy.Clinical and experimental hepatology · 2024Article
- Gestational hypercholanemia suppresses pregnancy-associated adipose mass increase and stimulates a pro-inflammatory environment in mice.Physiological reports · 2024Article
- Pregnancy cholestasis typically occurs in the third trimester of pregnancy and is a significant clinical condition.Archives of gynecology and obstetrics · 2024Article
- Extracellular vesicles: A potential new way to assess cholestasis.Obstetric medicine · 2024Article
- Obstetric cholestasis and its impact on the maternal outcome.Archives of gynecology and obstetrics · 2024Article
- Article
- Predictors of Adverse Fetal Outcomes in Intrahepatic Cholestasis of Pregnancy (ICP): a Narrative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Article
- Fetuin B may be a potential marker for predicting maternal and neonatal outcomes in intrahepatic cholestasis: Prospective case-control study.Turkish journal of obstetrics and gynecology · 2023Article
- The impact of intrahepatic cholestasis on pregnancy outcomes: a retrospective cohort study.BMC gastroenterology · 2023Article
- Rational use of drugs to alleviate adverse outcomes caused by COVID-19 quarantine in women with intrahepatic cholestasis of pregnancy.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious studies of fetal effects have suggested that intrahepatic cholestasis of pregnancy is associated with a higher rate of adverse neonatal outcomes including preterm birth, neonatal respiratory distress syndrome, meconium-stained amniotic fluid, neonatal intensive care unit admission, and stillbirth. The objective was to compare the neonatal and maternal consequences in pregnancies affected by intrahepatic cholestasis and normal pregnancies. MATERIAL AND
methodsThis case-control study compares pregnancies affected by intrahepatic cholestasis (pruritus and bile acid ≥ 10 μmol/L) with low-risk pregnancies managed between December 2006 and December 2014 at a French university hospital center.
resultsThere were 83 (59.3%) cases of mild cholestasis (10≤ BA ≤39 μmol/L), 46 (32.8%) of moderate cholestasis (40≤ BA ≤99 μmol/L), and 11 (7.9%) of severe cholestasis (BA ≥100 μmol/L). No in utero fetal deaths occurred in the 140 women with cholestasis or the 560 controls analyzed. The rate of respiratory distress syndrome was higher in neonates of women with intrahepatic cholestasis (17.1% vs. 4.6%, P<0.001; crude OR 4.46 (CI95% 2.49-8.03)). This risk was also significant after adjustment for gestational age at birth and mode of delivery, adjusted OR 2.56 (CI95%1.26-5.18). The postpartum hemorrhage rate was twice as high among the case mothers (25% versus 14.1% for controls, P = 0.002).
conclusionAfter adjustment on the confounding factors we found a higher rate of respiratory distress syndrome and neonatal morbidity among neonates of the cholestasis group.
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