Evidence map›Paper›PMID 32074081›Full record

ArticleAging2020

Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70.

Qin Chen, Minghan Huang, Jiayi Wu, Qiong Jiang, Xingchun Zheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  18. Neuroadaptive Biochemical Mechanisms of Remote Ischemic Conditioning.International journal of molecular sciences · 2023
    Review
  19. Review
  20. Exosomes for angiogenesis induction in ischemic disorders.Journal of cellular and molecular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Qin ChenDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China.
Minghan HuangThe Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Fuzhou, Fujian 350003, P.R. China.
Jiayi WuDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China.
Qiong JiangDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China.
Xingchun ZhengDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China.
Fujian Institute of Microbiology · CNUnion Hospital · CNFujian University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remote ischemic conditioning (RIC) is a promising therapeutic strategy to protect heart against ischemic-reperfusion injury. Exosomes have been proved to be an important regulator in many pathological processes. Whether the exosomes derived from RIC could improve cardiac remodeling and function after myocardial infarction (MI) has not been reported. MI animal model was established by ligating the left coronary artery. The bilateral hindlimbs of rats were subjected to RIC treatment using tourniquets. Exosomes were isolated from the plasma of RIC rats and identified by transmission electron microscope. The proliferation, migration, and apoptosis of endothelial cells were measured by CCK8, traswell, and flow cytometry. Western blotting, and qRT-PCR were applied to measure the expression of angiogenesis-related molecules, and immunohistochemistry staining was used to observe the expression of vWF. RIC and RIC exosomes remarkably facilitated cardiac function, cardiac cell remodeling, and angiogenesis. RIC exosomes markedly increased the cell ratio in the G1 phase, cell migration, cell proliferation, tube formation, and inhibited cell apoptosis through Hsp70. The expression of eNOS, iNOS, HIF-1α, Ang-1, and VEGF was markedly increased by RIC exosomes. RIC exosomes significantly improved cardiac function, cardiac remodeling, and angiogenesis after MI, and they accelerated angiogenesis through increasing the levels of angiogenesis-related molecules.

Indexed as

Ischemic PreconditioningAnimalsApoptosisCell ProliferationDisease Models, AnimalExosomesHeartHSP70 Heat-Shock ProteinsHypoxia-Inducible Factor 1, alpha SubunitMaleMyocardial InfarctionNeovascularization, PhysiologicNitric Oxide Synthase Type IIIRatsRats, WistarVascular Endothelial Growth Factor AHif1a protein, ratHSP70 Heat-Shock ProteinsHypoxia-Inducible Factor 1, alpha SubunitNitric Oxide Synthase Type IIIVascular Endothelial Growth Factor AexosomesHsp70myocardial infarctionremote ischemic conditioning

Identifiers

PMID32074081
PMCPMC7066898
OpenAlexW3007310854

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.