Evidence map›Paper›PMID 32073873›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Adipose-derived exosomes protect the pulmonary endothelial barrier in ventilator-induced lung injury by inhibiting the TRPV4/Ca

Qian Yu, Daoxin Wang, Xiaoting Wen, Xumao Tang, Di Qi, Jing He, Yan Zhao, Wang Deng, Tao Zhu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Qian YuDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Daoxin WangDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaoting WenDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xumao TangDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Di QiDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jing HeDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yan ZhaoDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wang DengDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tao ZhuDepartment of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Medical University · CNDalian Medical University · CNSecond Affiliated Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical ventilation (MV) is the main supportive treatment of acute respiratory distress syndrome (ARDS), but it may lead to ventilator-induced lung injury (VILI). Large epidemiological studies have found that obesity was associated with lower mortality in mechanically ventilated patients with acute lung injury, which is known as "obesity paradox." However, the effects of obesity on VILI are unknown. In the present study, wild-type mice were fed a high-fat diet (HFD) and ventilated with high tidal volume to investigate the effects of obesity on VILI in vivo, and pulmonary microvascular endothelial cells (PMVECs) were subjected to 18% cyclic stretching (CS) to further investigate its underlying mechanism in vitro. We found that HFD protects mice from VILI by alleviating the pulmonary endothelial barrier injury and inflammatory responses in mice. Adipose-derived exosomes can regulate distant tissues as novel adipokines, providing a new mechanism for cell-cell interactions. We extracted three adipose-derived exosomes, including HFD mouse serum exosome (S-Exo), adipose tissue exosome (AT-Exo), and adipose-derived stem cell exosome (ADSC-Exo), and further explored their effects on MV or 18% CS-induced VILI in vivo and in vitro. Administration of three exosomes protected against VILI by suppressing pulmonary endothelial barrier hyperpermeability, repairing the expression of adherens junctions, and alleviating inflammatory response in vivo and in vitro, accompanied by transient receptor potential vanilloid 4 (TRPV4)/Ca

Indexed as

Adherens JunctionsAnimalsCalciumCalcium SignalingEndothelial CellsExosomesLungMaleMiceMice, Inbred C57BLObesityRespiration, ArtificialRespiratory Distress SyndromeSignal TransductionTidal VolumeTRPV Cation ChannelsCalciumTrpv4 protein, mouseTRPV Cation Channelsadipose-derived exosomesinflammationpulmonary endothelial barrierTRPV4ventilator-induced lung injury (VILI)

Identifiers

PMID32073873
PMCPMC7191475
OpenAlexW3007909871

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.