Evidence map›Paper›PMID 32073726›Full record

ArticleJournal of thrombosis and haemostasis : JTH2020

Plasmin-mediated proteolysis of human factor IXa in the presence of calcium/phospholipid: Conversion of procoagulant factor IXa to a fibrinolytic enhancer.

Amy E Schmidt, Kanagasabai Vadivel, Julian Whitelegge, Satya Paul Bajaj

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amy E SchmidtDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, California.
Kanagasabai VadivelDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, California.
Julian WhiteleggeThe Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California.
Satya Paul BajajDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, California.
University of California, Los Angeles · US

Funding

Molecular and Structural Recognition in Factor VIIa Induced CoagulationR01HL141850 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VADIVEL, KANAGASABAI · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL141850
6 · The paper itself

Abstract

backgroundFactor (F) IX/IXa inactivation by plasmin has been studied; however, whether plasmin converts FIXa to a fibrinolytic enhancer is not known.

objectiveInvestigate plasmin proteolysis site(s) in FIXa that inactivates and transforms it into a fibrinolytic enhancer.

methodsNH

resultsPlasmin in the presence of Ca

conclusionPlasmin cleavage at Lys316↓Gly317 abrogates FIXaβ coagulant activity, whereas additional cleavage at Lys413↓Leu414 converts it into a fibrinolytic enhancer.

Indexed as

Factor IXaFibrinolysinCalciumHumansPhospholipidsProteolysisTissue Plasminogen ActivatorCalciumFactor IXaFibrinolysinPhospholipidsTissue Plasminogen Activatorfactor IXafar-western blotmass spectrometryproteolysistissue plasminogen activator

Identifiers

PMID32073726
PMCPMC7363452
OpenAlexW3007504317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.