Evidence map›Paper›PMID 32073188›Full record

ArticleClinical transplantation2020

Sex differences in eligibility for advanced heart failure therapies.

Rebecca S Steinberg, Aditi Nayak, Celena O'Connell, Sharon Burford, Ann Pekarek, Neile Chesnut, Robert T Cole, Divya Gupta, S Raja Laskar, Kunal Bhatt and 5 more

Open access · greenAbstract read
In one paragraph

Article in Clinical transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Advanced Heart Failure Characteristics and Outcomes in Women and Men.Journal of the American Heart Association · 2024
    Article
  5. Sex Differences in Cardiac Transplantation.Current atherosclerosis reports · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Rebecca S SteinbergDivision of Cardiology, Emory University, Atlanta, Georgia.
Aditi NayakDivision of Cardiology, Emory University, Atlanta, Georgia.
Celena O'ConnellEmory Healthcare, Emory Transplant Center, Atlanta, Georgia.
Sharon BurfordEmory Healthcare, Emory Transplant Center, Atlanta, Georgia.
Ann PekarekEmory Healthcare, Emory Transplant Center, Atlanta, Georgia.
Neile ChesnutEmory Healthcare, Emory Transplant Center, Atlanta, Georgia.
Robert T ColeInova Fairfox Hospital, Arlington, Virginia.
Divya GuptaDivision of Cardiology, Emory University, Atlanta, Georgia.
S Raja LaskarDivision of Cardiology, Emory University, Atlanta, Georgia.
Kunal BhattDivision of Cardiology, Emory University, Atlanta, Georgia.
Michael BurkeDivision of Cardiology, Emory University, Atlanta, Georgia.
Tamer AttiaDivision of Surgery, Emory University, Atlanta, Georgia.
Andrew SmithDivision of Cardiology, Emory University, Atlanta, Georgia.
J David VegaDivision of Surgery, Emory University, Atlanta, Georgia.
Alanna A MorrisDivision of Cardiology, Emory University, Atlanta, Georgia.ORCID 0000-0002-8033-3707
Emory University · USEmory Healthcare · USVirginia Hospital Center · US

Funding

TCC for Health Disparties: Informing & Influencing Health Policy and PracticeU54MD008173 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI SATCHER, DAVID · 2012 to 2016
$13.4M
Metabolomics, Oxidative Stress, and Vascular Function in Heart Failure PatientsK23HL124287 · NHLBI · EMORY UNIVERSITY · PI MORRIS, ALANNA AMYRE · 2015 to 2019
$804k
NHLBI NIH HHS K23 HL124287NIMHD NIH HHS U54 MD008173
6 · The paper itself

Abstract

objectivesWe investigated sex-based differences in eligibility for and outcomes after receipt of advanced heart failure (HF) therapies.

backgroundAlthough women are more likely to die from HF than men, registry data suggest that women are less likely to receive heart transplant (HT) or left ventricular assist device (LVAD) for largely unknown reasons.

methodsWe performed a single-center retrospective cohort study of patients evaluated for advanced HF therapies from 2012 to 2016. Logistic regression was used to determine the association of sex with eligibility for HT/LVAD. Competing risks and Kaplan-Meier analysis were used to examine survival.

resultsOf 569 patients (31% women) evaluated, 223 (39.2%) were listed for HT and 81 (14.2%) received destination (DT) LVAD. Women were less likely to be listed for HT (adjusted odds ratio [OR] 0.36, 95% confidence interval [CI] 0.21-0.61; P < .0001), based on allosensitization (P < .0001) and obesity (P = .02). Women were more likely to receive DT LVAD (adjusted OR 2.29, 95% CI 1.23-4.29; P = .01). Survival was similar between men and women regardless of whether they received HT and DT LVAD or were ineligible for therapy.

conclusionWomen are less likely to be HT candidates, but more likely to receive DT LVAD.

Indexed as

Heart-Assist DevicesHeart FailureHeart TransplantationAgedFemaleHumansMaleMedicareRetrospective StudiesSex CharacteristicsTreatment OutcomeUnited Statesdisparitiesheart failureheart transplantleft ventricular assist devicewomen

Identifiers

PMID32073188
PMCPMC7323365
OpenAlexW3006849217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.