Evidence map›Paper›PMID 32072970›Full record

ArticleComputers in biology and medicine2020

Predicting abdominal aortic aneurysm growth using patient-oriented growth models with two-step Bayesian inference.

Emrah Akkoyun, Sebastian T Kwon, Aybar C Acar, Whal Lee, Seungik Baek

Abstract read
In one paragraph

Article in Computers in biology and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  18. Predictors of Abdominal Aortic Aneurysm Risks.Bioengineering (Basel, Switzerland) · 2020
    Review
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Emrah AkkoyunDepartment of Health Informatics, Graduate School of Informatics, Middle East Technical University, Dumlupinar Bulvari #1, 06800, Cankaya, Ankara, Turkey.
Sebastian T KwonDepartment of Anesthesiology and Perioperative Medicine, UCLA David Geffen School of Medicine, 757 Westwood Blvd., Los Angeles, CA, 90095, USA.
Aybar C AcarDepartment of Health Informatics, Graduate School of Informatics, Middle East Technical University, Dumlupinar Bulvari #1, 06800, Cankaya, Ankara, Turkey.
Whal LeeDepartment of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, Republic of Korea.
Seungik BaekDepartment of Mechanical Engineering, Michigan State University, 2457 Engineering Building, East Lansing, MI, 48824, USA. Electronic address: sbaek@egr.msu.edu.

Funding

Growth and Remodeling Model of Abdominal Aortic Aneurysm: Toward Clinical ApplicaR01HL115185 · NHLBI · MICHIGAN STATE UNIVERSITY · PI BAEK, SEUNGIK · 2012 to 2015
$753k
Quantitative Analysis of Relationships Among Hemodynamics, Thrombus, and AbdominaR21HL113857 · NHLBI · MICHIGAN STATE UNIVERSITY · PI BAEK, SEUNGIK · 2013 to 2014
$384k
NHLBI NIH HHS R01 HL115185NHLBI NIH HHS R21 HL113857
6 · The paper itself

Abstract

objectiveFor small abdominal aortic aneurysms (AAAs), a regular follow-up examination is recommended every 12 months for AAAs of 30-39 mm and every six months for AAAs of 40-55 mm. Follow-up diameters can determine if a patient follows the common growth model of the population. However, the rapid expansion of an AAA, often associated with higher rupture risk, may be overlooked even though it requires surgical intervention. Therefore, the prognosis of abdominal aortic aneurysm growth is clinically important for planning treatment. This study aims to build enhanced Bayesian inference methods to predict maximum aneurysm diameter.

methods106 CT scans from 25 Korean AAA patients were retrospectively obtained. A two-step approach based on Bayesian calibration was used, and an exponential abdominal aortic aneurysm growth model (population-based) was specified according to each individual patient's growth (patient-specific) and morphologic characteristics of the aneurysm sac (enhanced). The distribution estimates were obtained using a Markov Chain Monte Carlo (MCMC) sampler.

resultsThe follow-up diameters were predicted satisfactorily (i.e. the true follow-up diameter was in the 95% prediction interval) for 79% of the scans using the population-based growth model, and 83% of the scans using the patient-specific growth model. Among the evaluated geometric measurements, centerline tortuosity was a significant (p = 0.0002) predictor of growth for AAAs with accelerated and stable expansion rates. Using the enhanced prediction model, 86% of follow-up scans were predicted satisfactorily. The average prediction errors of population-based, patient-specific, and enhanced models were ±2.67, ±2.61 and ± 2.79 mm, respectively.

conclusionA computational framework using patient-oriented growth models provides useful tools for per-patient basis treatment and enables better prediction of AAA growth.

Indexed as

Aortic Aneurysm, AbdominalBayes TheoremHumansRetrospective StudiesRisk FactorsTime FactorsTomography, X-Ray ComputedAbdominal aortic aneurysmBayesian inferencePatient-oriented prediction modelProbabilistic programmingRupture risk assessment

Identifiers

PMID32072970
PMCPMC7064358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.