ReviewDevelopmental cognitive neuroscience2020
The relationship between pubertal hormones and brain plasticity: Implications for cognitive training in adolescence.
Review in Developmental cognitive neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05879198 (Train Your Brain), which is not on this map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Train Your Brain: A Pilot Project to Improve Memory and Decision Making to Improve Outcomes Among Youth
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Pooled it
- Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies.Frontiers in human neuroscience · 2020Pooled it
- Heightened sensitivity to the caregiving environment during adolescence: implications for recovery following early-life adversity.Journal of child psychology and psychiatry, and allied disciplines · 2021Trial
- Working memory and daily internalizing problems: Pubertal timing moderates adult relations.Journal of affective disorders · 2026Article
- Longitudinal associations between sedentary behavior types and mathematics ability mediated by externalizing and internalizing problems.NPJ science of learning · 2026Article
- Structural MRI assessment of hypothalamic alterations and cognitive implications in adolescents with rapid pubertal progression.BMC medical imaging · 2026Article
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Safety-relevant experience reshapes neural codes for ambiguous threat in adolescents.Social cognitive and affective neuroscience · 2026Article
- Sex Specific Threshold Effects of Prenatal Stress on Striatal Microglia and Relevant Behaviors in Mice.Archives of medical research · 2026Article
- Neurotrophic Control of Puberty: From Molecular Signaling to Disorders of Pubertal Timing.Current issues in molecular biology · 2025Review
- Article
- The Relationship of Need for Cognition and Typical Intellectual Engagement with Intelligence and Executive Functions: A Multi-Level Meta-Analysis.Journal of Intelligence · 2025Review
- Article
- Executive Functioning and Mental Health in Adolescent Kidney Transplant Candidates During the COVID-19 Pandemic.Pediatric transplantation · 2025Article
- A Narrative Inquiry Into Problematic Internet Use Among Young Adults: A Narrative Review.Cureus · 2025Review
- Intensive task-switching training and single-task training differentially affect behavioral and neural manifestations of cognitive control in children.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Early-Life Adversity Predicts Markers of Aging-Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women.Annals of neurology · 2025Article
- Article
- Comparative study of the effects of VBT training with different velocity loss thresholds on lower limb explosive force of adolescent sprinters.Frontiers in physiology · 2025Article
- Developmental shifts in testosterone levels are associated with alterations in the neural oscillatory dynamics serving selective attention.Imaging neuroscience (Cambridge, Mass.) · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Adolescence may mark a sensitive period for the development of higher-order cognition through enhanced plasticity of cortical circuits. At the same time, animal research indicates that pubertal hormones may represent one key mechanism for closing sensitive periods in the associative neocortex, thereby resulting in decreased plasticity of cortical circuits in adolescence. In the present review, we set out to solve some of the existing ambiguity and examine how hormonal changes associated with pubertal onset may modulate plasticity in higher-order cognition during adolescence. We build on existing age-comparative cognitive training studies to explore how the potential for change in neural resources and behavioral repertoire differs across age groups. We review animal and human brain imaging studies, which demonstrate a link between brain development, neurochemical mechanisms of plasticity, and pubertal hormones. Overall, the existent literature indicates that pubertal hormones play a pivotal role in regulating the mechanisms of experience-dependent plasticity during adolescence. However, the extent to which hormonal changes associated with pubertal onset increase or decrease brain plasticity may depend on the specific cognitive domain, the sex, and associated brain networks. We discuss implications for future research and suggest that systematical longitudinal assessments of pubertal change together with cognitive training interventions may be a fruitful way toward a better understanding of adolescent plasticity. As the age of pubertal onset is decreasing across developed societies, this may also have important educational and clinical implications, especially with respect to the effects that earlier puberty has on learning.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.