Evidence map›Paper›PMID 32072628›Full record

ArticleEpilepsia2020

Optogenetic intervention of seizures improves spatial memory in a mouse model of chronic temporal lobe epilepsy.

Hannah K Kim, Tilo Gschwind, Theresa M Nguyen, Anh D Bui, Sylwia Felong, Kristen Ampig, David Suh, Annie V Ciernia, Marcelo A Wood, Ivan Soltesz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. GABAFrontiers in neural circuits · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hannah K KimDepartment of Neurosurgery, Stanford University, Stanford, California.ORCID 0000-0003-3478-2883
Tilo GschwindDepartment of Neurosurgery, Stanford University, Stanford, California.
Theresa M NguyenDepartment of Neurosurgery, Stanford University, Stanford, California.
Anh D BuiDepartment of Neurosurgery, Stanford University, Stanford, California.
Sylwia FelongDepartment of Neurosurgery, Stanford University, Stanford, California.
Kristen AmpigDepartment of Anatomy and Neurobiology, University of California, Irvine, California.
David SuhDepartment of Anatomy and Neurobiology, University of California, Irvine, California.
Annie V CierniaDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, California.
Marcelo A WoodDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, California.
Ivan SolteszDepartment of Neurosurgery, Stanford University, Stanford, California.ORCID 0000-0003-1493-3744
Stanford University · USUniversity of California, Irvine · USVancouver Coastal Health · CA

Funding

Epilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9M
Closed-loop intervention in epilepsy.R01NS094668 · NINDS · STANFORD UNIVERSITY · PI LOSONCZY, ATTILA, SOLTESZ, IVAN · 2015 to 2019
$2.3M
Functional Organization of the Myelin MembraneF31NS045440 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI TAYLOR, CHRISTOPHER M · 2003 to 2003
$18k
NINDS NIH HHS F31 NS045440NINDS NIH HHS R01 NS094668NINDS NIH HHS T32 NS045540Swiss League Against Epilepsy RRA2016
6 · The paper itself

Abstract

objectiveTo determine if closed-loop optogenetic seizure intervention, previously shown to reduce seizure duration in a well-established mouse model chronic temporal lobe epilepsy (TLE), also improves the associated comorbidity of impaired spatial memory.

methodsMice with chronic, spontaneous seizures in the unilateral intrahippocampal kainic acid model of TLE, expressing channelrhodopsin in parvalbumin-expressing interneurons, were implanted with optical fibers and electrodes, and tested for response to closed-loop light intervention of seizures. Animals that responded to closed-loop optogenetic curtailment of seizures were tested in the object location memory test and then given closed-loop optogenetic intervention on all detected seizures for 2 weeks. Following this, they were tested with a second object location memory test, with different objects and contexts than used previously, to assess if seizure suppression can improve deficits in spatial memory.

resultsAnimals that received closed-loop optogenetic intervention performed significantly better in the second object location memory test compared to the first test. Epileptic controls with no intervention showed stable frequency and duration of seizures, as well as stable spatial memory deficits, for several months after the precipitating insult. SIGNIFICANCE: Many currently available treatments for epilepsy target seizures but not the associated comorbidities, therefore there is a need to investigate new potential therapies that may be able to improve both seizure burden and associated comorbidities of epilepsy. In this study, we showed that optogenetic intervention may be able to both shorten seizure duration and improve cognitive outcomes of spatial memory.

Indexed as

InterneuronsSpatial LearningSpatial MemoryAnimalsChannelrhodopsinsChronic DiseaseCognitive DysfunctionDisease Models, AnimalElectroencephalographyEpilepsy, Temporal LobeExcitatory Amino Acid AgonistsHippocampusKainic AcidMiceOptogeneticsParvalbuminsChannelrhodopsinsExcitatory Amino Acid AgonistsKainic AcidParvalbuminsbehaviorclosed-loopcognitive impairmentcomorbiditytemporal lobe epilepsy

Identifiers

PMID32072628
PMCPMC7708390
OpenAlexW3008485881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.