ArticleActa obstetricia et gynecologica Scandinavica2020
Risk of adverse pregnancy outcomes of late- and postterm pregnancies in advanced maternal age: A national cohort study.
Article in Acta obstetricia et gynecologica Scandinavica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Maternal age 30-34 years and adverse perinatal outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Membrane sweeping in term pregnancy to promote spontaneous labor and prevent post-term pregnancy: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- The role of mitochondrial fusion protein 2 in regulating ER stress in premature placental aging: A case-control study.Medicine · 2026Article
- Genomic risk profiling in advanced maternal age: a Tamil Nadu prenatal study.Frontiers in medicine · 2026Article
- Global burden of female infertility attributable to sexually transmitted infections and maternal sepsis: 1990-2021 and projections to 2050.Scientific reports · 2025Article
- Adverse obstetrical outcomes among adolescents in North Wollo Zone Governmental hospitals, Northern Ethiopia.Scientific reports · 2025Article
- Vaginal bleeding during pregnancy: a retrospective cohort study assessing maternal and perinatal outcomes.The Journal of international medical research · 2025Article
- Comparing adverse maternal outcomes among adolescent and adult women in North Wollo Zone governmental hospitals, northern Ethiopia.Frontiers in global women's health · 2025Article
- Determinants of Neonatal Mortality at a Referral Paediatric Hospital in Angola: A Case-Control Study Using Theoretical Frameworks.International journal of environmental research and public health · 2024Article
- Status, outcome, and related factors of postpartum hypertension in the Shanghai community.World journal of clinical cases · 2024Article
- The role of the cerebroplacental ratio in predicting pregnancy outcomes at 40-42 gestational weeks: a prospective observational trial.Archives of gynecology and obstetrics · 2024Observational
- Maternal and perinatal outcomes of oligohydramnios in late term and post term pregnancies at public hospitals in Ethiopia: a cross-sectional study.BMC women's health · 2024Article
- Changes in the characteristics and outcomes of high-risk pregnant women who delivered prior to and after China's universal two-child policy: a real-world retrospective study, 2010-2021.BMC public health · 2024Article
- An investigation of the umbilical artery N-terminal proBrain natriuretic peptide levels of fetuses due to fetal distress in term pregnancies.Revista da Associacao Medica Brasileira (1992) · 2024Article
- The Prediction of IVF Outcomes with Autologous Oocytes and the Optimal MII Oocyte/Embryo Number for Live Birth at Advanced Maternal Age.Medicina (Kaunas, Lithuania) · 2023Article
- Predicting labor onset relative to the estimated date of delivery using smart ring physiological data.NPJ digital medicine · 2023Article
- Retrospective Study of First Trimester Metrorrhagia: Pregnancy Follow-Up and Relationship with the Appearance of Gestational Complications.Medicina (Kaunas, Lithuania) · 2023Article
- DNA methylation abnormalities induced by advanced maternal age in villi prime a high-risk state for spontaneous abortion.Clinical epigenetics · 2023Article
- Association between very advanced maternal age women with gestational diabetes mellitus and the risks of adverse infant outcomes: a cohort study from the NVSS 2014-2019.BMC pregnancy and childbirth · 2023Article
- The interaction between age and parity on adverse pregnancy and neonatal outcomes.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThere is an increase in women delivering ≥35 years of age. We analyzed the association between advanced maternal age and pregnancy outcomes in late- and postterm pregnancies. MATERIAL AND
methodsA national cohort study was performed on obstetrical low-risk women using data from the Netherlands Perinatal Registry from 1999 to 2010. We included women ≥18 years of age with a singleton pregnancy at term. Women with a pregnancy complicated by congenital anomalies, hypertensive disorders or diabetes mellitus were excluded. Composite adverse perinatal outcome was defined as stillbirth, neonatal death, meconium aspiration syndrome, 5-minute Apgar score <7, neonatal intensive care unit admittance and sepsis. Composite adverse maternal outcome was defined as maternal death, placental abruption and postpartum hemorrhage of >1000 mL.
resultsWe stratified the women into three age groups: 18-34 (n = 1 321 366 [reference]); 35-39 (n = 286 717) and ≥40 (n = 40 909). Composite adverse perinatal outcome occurred in 1.6% in women aged 18-34, 1.7% in women aged 35-39 (relative risk [RR] 1.06, 95% confidence interval [95% CI] 1.03-1.08) and 2.2% in women aged ≥40 (RR 1.38, 95% CI 1.29-1.47), with 5-minute Apgar score <7 as the factor contributing most to the outcome. Composite adverse maternal outcome occurred in 4.6% in women aged 18-34, 5.0% in women aged 35-39 (RR 1.08, 95% CI 1.06-1.10) and 5.2% in women aged ≥40 (RR 1.14, 95% CI 1.09-1.19), with postpartum hemorrhage >1000 mL as the factor contributing most to the outcome. In all age categories, the risk of adverse pregnancy outcomes was higher for nulliparous than for multiparous women. The risk of adverse outcomes increased in both nulliparous and parous women with advancing gestational age. When adjusted for parity, onset of labor and gestational age, advanced maternal age is associated with an increase in both composite adverse perinatal and maternal outcomes.
conclusionsThe risk of adverse pregnancy outcome increases with advancing maternal age. Women aged ≥40 have an increased risk of adverse perinatal and maternal outcome when pregnancy goes beyond 41 weeks.
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