ArticleInternational urology and nephrology2020
Development and validation of prognostic nomograms in patients with adrenocortical carcinoma: a population-based study.
Article in International urology and nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Serum Steroid Profiling in the Diagnosis of Adrenocortical Carcinoma: A Prospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Prognostic factors of adrenocortical carcinoma in children and adolescents: a population-based study.International urology and nephrology · 2024Article
- A prognostic framework for predicting lung signet ring cell carcinoma via a machine learning based cox proportional hazard model.Journal of cancer research and clinical oncology · 2024Article
- S-GRAS score performs better than a model from SEER for patients with adrenocortical carcinoma.Endocrine connections · 2022Article
- Establishment of prognostic models of adrenocortical carcinoma using machine learning and big data.Frontiers in surgery · 2022Article
- Comparative performances of nomograms and conditional survival after resection of adrenocortical cancer.BJS open · 2021Observational
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Authors and funding
6 authors.
Funding
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Abstract
backgroundPredicting the prognosis of patients with adrenocortical carcinoma (ACC) is difficult, due to its unpredictable behavior. The aim of this study is to develop and validate a nomogram to predict survival outcomes in patients with ACC.
methodsNomograms were established using the data collected from the Surveillance, Epidemiology, and End Results (SEER) database. Based on univariate and multivariate Cox regression analyses, we identified independent risk factors for overall survival (OS) and cancer-specific survival (CSS). Concordance indexes (c-indexes), the area under the receiver operating characteristics curve (AUC) and calibration curve were used to evaluate predictive performance of these models. The clinical use of nomogram was measured by decision curve analysis (DCA) and clinical impact curves.
resultsA total of 855 eligible patients, randomly divided into training (n = 600) and validation cohorts (n = 255), were included in this study. Based on the independent predictors, the nomograms were established and demonstrated good discriminative abilities, with C-indexes for OS and CSS were 0.762 and 0.765 in training cohorts and 0.738 and 0.758 in validation cohorts, respectively. The AUC and calibration plots also demonstrated a good performance for both nomograms. DCA indicated that the two nomograms provide clinical net benefits.
conclusionWe unveiled the prognostic factors of ACC and developed novel nomograms that predict OS and CSS more accurately and comprehensively, which can help clinicians improve individual treatment, making proper clinical decisions and adjusting follow-up management strategies.
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