ArticleClinical research in cardiology : official journal of the German Cardiac Society2020
Prognosis of persistent mitral regurgitation in patients undergoing transcatheter aortic valve replacement.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 32 citations in OpenAlex.
- Relationship Between Position, Shape, and Deformation of Papillary Muscles and Mitral Regurgitation After Transcatheter Aortic Valve Replacement.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- The evolution of concomitant mitral regurgitation in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: a prospective multi-center China-DVD2 cohort study.Cardiology journal · 2026Article
- Risk factors and predictive models for post-operative moderate-to-severe mitral regurgitation following transcatheter aortic valve replacement: a machine learning approach.BMC cardiovascular disorders · 2025Article
- Evolution of Untreated Moderate Mitral Regurgitation After Transcatheter Aortic Valve Implantation.Medicina (Kaunas, Lithuania) · 2025Article
- A composite index for predicting improvement of mitral regurgitation in patients with multivalvular heart disease after transcatheter aortic valve replacement.Frontiers in cardiovascular medicine · 2025Article
- Transcatheter Aortic Valve Implantation Indications and Patient Selection.Interventional cardiology (London, England) · 2025Review
- Case Report: Concurrent transcatheter aortic and mitral valve replacement for symptomatic concomitant aortic and mitral valve stenoses.Frontiers in cardiovascular medicine · 2024Article
- The impact of transcatheter aortic valve implantation (TAVI) on mitral regurgitation - a single center study.Cardiology journal · 2024Article
- Bioprosthetic Valves for Lifetime Management of Aortic Stenosis: Pearls and Pitfalls.Journal of clinical medicine · 2023Review
- Prognostic Impact of Residual Moderate Mitral Regurgitation Following Valve-in-Valve Transcatheter Aortic Valve Implantation.Brazilian journal of cardiovascular surgery · 2023Article
- Transcatheter mitral valve implantation using the Tendyne valve in a patient with prior transcatheter aortic valve implantation: a case report.European heart journal. Case reports · 2023Article
- Prognostic Impact of Mitral Regurgitation Before and After Transcatheter Aortic Valve Replacement in Patients With Severe Low-Flow, Low-Gradient Aortic Stenosis.Journal of the American Heart Association · 2023Article
- Echocardiographic Evaluation after Transcatheter Aortic Valve Implantation: A Comprehensive Review.Life (Basel, Switzerland) · 2023Review
- The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation.Journal of clinical medicine · 2021Article
- Kidney injury as post-interventional complication of TAVI.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Review
- Mixed-Valve Disease: Management of Patients with Aortic Stenosis and Mitral Regurgitation: Thresholds for Surgery Versus Percutaneous Therapies.US cardiology · 2021Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to assess imaging predictors of mitral regurgitation (MR) improvement and to evaluate the impact of MR regression on long-term outcome in patients undergoing transcatheter aortic valve replacement (TAVR).
backgroundConcomitant MR is a frequent finding in patients with severe aortic stenosis but usually left untreated at the time of TAVR.
methodsMitral regurgitation was graded by transthoracic echocardiography before and after TAVR in 677 consecutive patients with severe aortic stenosis. 2-year mortality was related to the degree of baseline and discharge MR. Morphological echo analysis was performed to determine predictors of MR improvement.
results15.2% of patients presented with baseline MR ≥ 3 +, which was associated with a significantly decreased 2-year survival (57.7% vs. 74.4%, P < 0.001). MR improved in 50% of patients following TAVR, with 44% regressing to MR ≤ 2 +. MR improvement to ≤ 2 + was associated with significantly better survival compared to patients with persistent MR ≥ 3 +. Baseline parameters including non-severe baseline MR, the extent of mitral annular calcification and large annular dimension (≥ 32 mm) predicted the likelihood of an improvement to MR ≤ 2 +. A score based on these parameters selected groups with differing probability of MR ≤ 2 + post TAVR ranging from 10.5 to 94.4% (AUC 0.816; P < 0.001), and was predictive for 2-year mortality.
conclusionUnresolved severe MR is a critical determinant of long term mortality following TAVR. Persistence of severe MR following TAVR can be predicted using selected parameters derived from TTE-imaging. These data call for close follow up and additional mitral valve treatment in this subgroup. Factors associated with MR persistence or regression after TAVR.
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