Evidence map›Paper›PMID 32072102›Full record

ArticlePain reports

Pain-related anxiety promotes pronociceptive processes in Native Americans: bootstrapped mediation analyses from the Oklahoma Study of Native American Pain Risk.

Jamie L Rhudy, Felicitas Huber, Bethany L Kuhn, Edward W Lannon, Shreela Palit, Michael F Payne, Natalie Hellman, Cassandra A Sturycz, Yvette M Güereca, Tyler A Toledo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jamie L RhudyDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Felicitas HuberDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Bethany L KuhnDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Edward W LannonDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Shreela PalitDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Michael F PayneDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Natalie HellmanDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Cassandra A SturyczDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Yvette M GüerecaDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Tyler A ToledoDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Mara J DemuthDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Burkhart J HahnDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
Joanna O ShadlowDepartment of Psychology, The University of Tulsa, Tulsa, OK, USA.
University of Tulsa · US

Funding

the Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) ProgramT32AG049673 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2015 to 2024
$3.2M
Native American Pain Disparities: Exploring Nociceptive Processing DifferencesR01MD007807 · NIMHD · UNIVERSITY OF TULSA · PI RHUDY, JAMIE LYNN · 2013 to 2016
$1.2M
NIA NIH HHS T32 AG049673NIMHD NIH HHS R01 MD007807
6 · The paper itself

Abstract

introductionEvidence suggests Native Americans (NAs) experience higher rates of chronic pain than the general US population, but the mechanisms contributing to this disparity are poorly understood. Recently, we conducted a study of healthy, pain-free NAs (n = 155), and non-Hispanic whites (NHWs, n = 150) to address this issue and found little evidence that NAs and NHWs differ in pain processing (assessed from multiple quantitative sensory tests). However, NAs reported higher levels of pain-related anxiety during many of the tasks.

objectiveThe current study is a secondary analysis of those data to examine whether pain-related anxiety could promote pronociceptive processes in NAs to put them at chronic pain risk.

methodsBootstrapped indirect effect tests were conducted to examine whether pain-related anxiety mediated the relationships between race (NHW vs NA) and measures of pain tolerance (electric, heat, ischemia, and cold pressor), temporal summation of pain and the nociceptive flexion reflex (NFR), and conditioned pain modulation of pain/NFR.

resultsPain-related anxiety mediated the relationships between NA race and pain tolerance and conditioned pain modulation of NFR. Exploratory analyses failed to show that race moderated relationships between pain-related anxiety and pain outcomes.

conclusionThese findings imply that pain-related anxiety is not a unique mechanism of pain risk for NAs, but that the greater tendency to experience pain-related anxiety by NAs impairs their ability to engage descending inhibition of spinal nociception and decreases their pain tolerance (more so than NHWs). Thus, pain-related anxiety may promote pronociceptive processes in NAs to place them at risk for future chronic pain.

Indexed as

Ethnic differencesMediationNative AmericansPain modulationPain-related affectQuantitative sensory testing

Identifiers

PMID32072102
PMCPMC7004502
OpenAlexW3003410871

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.