ArticlePain reports
The feasibility and acceptability of research magnetic resonance imaging in adolescents with moderate-severe neuropathic pain.
Article in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Biomarkers and Psychological Factors Associated with Distress in Children, Adolescents, and Young Adults Undergoing MRI Neuroimaging: A Systematic Review of Observational Studies with Clinical Recommendations.Healthcare (Basel, Switzerland) · 2026Review
- Barriers and facilitators for participation in brain magnetic resonance imaging (MRI) scans in cancer research: a feasibility and acceptability analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Amygdalar Functional Connectivity Differences Associated With Reduced Pain Intensity in Pediatric Peripheral Neuropathic Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations.Canadian journal of pain = Revue canadienne de la douleur · 2022Review
- Development of a Super-Resolution Scheme for Pediatric Magnetic Resonance Brain Imaging Through Convolutional Neural Networks.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMultimodal characterisation with questionnaires, Quantitative Sensory Testing (QST), and neuroimaging will improve understanding of neuropathic pain (NeuP) in adolescents. Magnetic resonance imaging (MRI) data in adolescents with NeuP are limited, and the perceived practical or ethical burden of scanning may represent a barrier to research.
objectiveTo determine the feasibility of MRI scanning in adolescents with moderate-severe NeuP, with respect to consent rate, postscan acceptability, and data quality.
methodsThis prospective cohort study evaluating questionnaires and QST recruited adolescents aged 10 to 18 years with clinically diagnosed NeuP from a tertiary clinic. Eligible adolescents aged 11 years and older could additionally agree/decline an MRI scan. After the scan, families rated discomfort, perceived risk, and acceptability of current and future MRI scans (0-10 numerical rating scales). Head motion during scanning was compared with healthy controls to assess data quality.
resultsThirty-four families agreed to MRI (72% recruitment), and 21 adolescents with moderate-severe pain (average last week 6.7 ± 1.7; mean ± SD) and with neuropathic QST profiles were scanned. Three adolescents reported positional or noise-related discomfort during scanning. Perceived risk was low, and acceptability of the current scan was high for parents (range [median]: 7 to 10/10 [10]) and adolescents (8-10/10 [10]). Willingness to undergo a future research scan was high for parents (7-10/10 [10]) and adolescents (5-10/10 [10]) and did not differ from future scans for clinical purposes. Mean head motion during resting state functional MRI did not differ from control adolescents.
conclusionResearch MRI is feasible and acceptable for many adolescents with moderate-severe NeuP.
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