Evidence map›Paper›PMID 32072078›Full record

ArticleBioactive materials2020

Recruitment of endogenous progenitor cells by erythropoietin loaded particles for in situ cartilage regeneration.

Amirhossein Hakamivala, Shuxin Li, Kayti Robinson, YiHui Huang, Shuai Yu, Baohong Yuan, Joseph Borrelli, Liping Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Biomolecule-releasing bioadhesive for glenoid labrum repair through induced host progenitor cell responses.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Amirhossein HakamivalaBioengineering Department, University of Texas Southwestern Medical Center, The University of Texas at Arlington, Arlington, TX, 76019, USA.
Shuxin LiBioengineering Department, University of Texas Southwestern Medical Center, The University of Texas at Arlington, Arlington, TX, 76019, USA.
Kayti RobinsonDepartment of Biology, The University of Texas at Arlington, Arlington, TX, 76019, USA.
YiHui HuangBioengineering Department, University of Texas Southwestern Medical Center, The University of Texas at Arlington, Arlington, TX, 76019, USA.
Shuai YuBioengineering Department, University of Texas Southwestern Medical Center, The University of Texas at Arlington, Arlington, TX, 76019, USA.
Baohong YuanBioengineering Department, University of Texas Southwestern Medical Center, The University of Texas at Arlington, Arlington, TX, 76019, USA.
Joseph BorrelliBioengineering Department, University of Texas Southwestern Medical Center, The University of Texas at Arlington, Arlington, TX, 76019, USA.
Liping TangBioengineering Department, University of Texas Southwestern Medical Center, The University of Texas at Arlington, Arlington, TX, 76019, USA.
The University of Texas at Arlington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage injury affects millions of people throughout the world, and at this time there is no cure. While transplantation of stem cells has shown some success in the treatment of injured cartilage, such treatment is limited by limited cell sources and safety concerns. To overcome these drawbacks, a microscaffolds system was developed capable of targeting, reducing the inflammatory response and recruiting endogenous progenitor cells to cartilage-defect. Erythropoietin (EPO)-loaded-hyaluronic acid (HA) microscaffolds (HA + EPO) were fabricated and characterized. HA-microscaffolds showed good cell-compatibility and could target chondrocytes via CD44 receptors. HA + EPO was designed to slowly release EPO while recruiting progenitor cells. Finally, the ability of HA + EPO to repair cartilage-defects was assessed using a rabbit model of full-thickness cartilage-defect. Our results showed that the intra-articular administration of EPO, HA, and EPO + HA reduced the number of inflammatory cells inside the synovial-fluid, while EPO + HA had the greatest anti-inflammatory effects. Furthermore, among all groups, EPO + HA achieved the greatest progenitor cell recruitment and subsequent chondrogenesis. The results of this work support that, by targeting and localizing the release of growth-factors, HA + EPO can reduce inflammatory responses and promote progenitor cells responses. This new platform represents an alternative treatment to stem-cell transplantation for the treatment of cartilage injury.

Indexed as

Cartilage injuryChondrogenesisErythropoietinHyaluronic acid microscaffoldsProgenitor cells recruitment

Identifiers

PMID32072078
PMCPMC7011041
OpenAlexW3005475887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.