Evidence map›Paper›PMID 32072035›Full record

ArticleHeliyon2020

Annexin 2 protein expression is associated with breast cancer subtypes in African American women.

Desta A Beyene, Norma F Kanarek, Tammey J Naab, Luisel L Ricks-Santi, Tamaro S Hudson

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Desta A BeyeneDepartment of Biochemistry and Molecular Biology, Howard University, Washington, DC, USA.
Norma F KanarekDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health and Department of Oncology, Johns Hospital School of Medicine, USA.
Tammey J NaabDepartment of Pathology, College of Medicine, Howard University, Washington, DC, USA.
Luisel L Ricks-SantiDepartment of Biological Sciences, Cancer Research Center, Hampton University, Hampton, VA, USA.
Tamaro S HudsonDepartment of Research, Veteran Affairs Medical Center, Washington, DC, USA.
Howard University · USHampton University · USJohns Hopkins University · US

Funding

Functional analysis of genetic variants in African Americans with Breast CancerR15CA239100 · NCI · HAMPTON UNIVERSITY · PI MCDONALD, JOHN TYSON, RICKS-SANTI, LUISEL J. · 2019 to 2019
$444k
A Biomarker Risk Prediction Model for Prostate CancerIK2RX001114 · VA · U.S. DEPT/VETS AFFAIRS MEDICAL CENTER · PI HUDSON, TAMARO SYTON · 2015 to 2020
–
NCI NIH HHS R15 CA239100RRD VA IK2 RX001114
6 · The paper itself

Abstract

backgroundA review of literature on the expression of Annexin 2 in cancer has shown that there is very limited research work on the association of this protein with breast cancer aggressiveness in African Americans. In the present study, TMA breast tissues from African American women were stained with Annexin 2 antibody to determine the association between the molecular subtypes and Annexin 2 protein expression.

methodAn annotated case series of 135 breast cancer tissues archived from 2000 to 2010 was acquired from the Howard University Tumor Registry. The association between ANX2 expression and survival by molecular subtypes Luminal A, Luminal B, HER2, and Triple Negative (TN) was assessed using Multinomial regression, chi-square analysis, and Kaplan-Meir graphs (Stata 11).

resultsOur findings show a marked association between ANX2 protein expression in Luminal B and HER2 subtypes unadjusted and when adjusted for age. Borderline differences in tumor grade were found in TN only.Univariately, age (<50, 50 + years) and metastases were highly significant for overall survival, disease-free survival and recurrence-free survival. Stage, tumor size, and nodal involvement were of borderline or greater significance for overall and disease-free survival. ANX2 expression was not significant. Kaplan Meier tests of ANX2 showed significant separation of overall survival by ANX2 protein expression in all breast tumor subtypes. In multivariate analyses comparing TN to Luminal A, ANX2 was not important while controlling for age and grade.

conclusionANX2 might be a biomarker of aggressiveness and a relevant candidate biomarker in high risk African American women with Luminal B and HER2 breast cancer.

Indexed as

Annexin 2Breast cancerCancer researchEpidemiologyHER2ImmunohistochemistryLuminal ALuminal BMolecular biologyOverall survivalPathophysiologyProteinsRecurrence-free survivalTriple negative

Identifiers

PMID32072035
PMCPMC7011040
OpenAlexW3004792311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.