ArticleEuropean thyroid journal2020
Levothyroxine Absorption Test to Differentiate Pseudomalabsorption from True Malabsorption.
Article in European thyroid journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism.European thyroid journal · 2025Guideline
- Thyroxine binding globulin deficiency due to a novelJCEM case reports · 2026Article
- [Evaluation of sodium levothyroxine absorption in real clinical practice using a single-bolus oral test].Problemy endokrinologii · 2026Article
- The gut-thyroid axis: physiological regulation of barrier function, microbiota, endocrine signaling and the consequences on energy metabolism.Frontiers in physiology · 2026Review
- National recommendations of the Croatian society of medical biochemistry and laboratory medicine: Thyroid function tests from the laboratory point of view.Biochemia medica · 2025Review
- Levothyroxine absorption test in patients with refractory hypothyroidism: how to interpret patient's response to the test?Endocrine · 2025Article
- Refractory Hypothyroidism: Unexpected Outcome During Treatment of Giant Cell Arteritis.Clinical case reports · 2025Article
- Apalutamide treatment and refractory hypothyroidism: effects of apalutamide on levothyroxine metabolism.European thyroid journal · 2025Article
- Pseudo-Malabsorption in High Dose Levothyroxine-Resistant Hypothyroidism.JCEM case reports · 2025Article
- Intramuscular and subcutaneous levothyroxine: success in treating refractory hypothyroidism.European thyroid journal · 2025Article
- Levothyroxine Absorption Test With the Daily Levothyroxine Dose in Patients With "Refractory Hypothyroidism".Journal of the Endocrine Society · 2025Article
- Rapid supervised levothyroxine absorption test in refractory hypothyroidism: suggestion for assessing absorption using two blood samples in low-resource settings.Endocrine connections · 2024Article
- Article
- Levothyroxine absorption test followed by directly observed treatment on an outpatient basis to address long-term high thyrotropin levels in a hypothyroid patient: a case report.Journal of medical case reports · 2023Article
- Levothyroxine liquid oral substitution as an alternative treatment for refractory hypothyroidism due to gastrointestinal malabsorption: A case report.SAGE open medical case reports · 2023Article
- Levothyroxine malabsorption or pseudomalabsorption? A question in the management of refractory hypothyroidism.Endocrine connections · 2022Article
- Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults.Reviews in endocrine & metabolic disorders · 2022Review
- SEVERE REFRACTORY HYPOTHYROIDISM IN A 48-YEAR-OLD FEMALE: ROLE OF LOW-DOSE THYROXINE ABSORPTION TEST IN ESTABLISHING DIAGNOSIS OF NONCOMPLIANCE.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Daily Intramuscular Levothyroxine in Refractory Hypothyroidism and Malabsorption.AACE endocrinology and diabetesArticle
- Levothyroxine Absorption Test - Results and Follow Up of Patients from a Single Center.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe levothyroxine absorption test for evaluation of pseudomalabsorption in patients with primary hypothyroid is not standardised. An individual in whom a workup for malabsorption is warranted remains undefined.
methodsTwenty-five euthyroid, 25 newly diagnosed hypothyroid, 25 treated hypothyroid with normalised TSH, and 25 hypothyroid subjects with elevated TSH despite adequate dose of levothyroxine for more than 6 months, and 10 euthyroid subjects with true malabsorption were administered levothyroxine (10 μg/kg or maximum 600 μg) to study its absorption profile by measuring free T4 level at hourly intervals for 5 h.
conclusionSubjects with elevated TSH on adequate dose of LT4 can be reliably diagnosed to be non-adherent to treatment with levothyroxine absorption test. The incremental value above 0.40 ng/dL (5.14 pmol/L) at 3 h may be useful to identify individuals where workup of malabsorption is unwarranted.
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