ReviewMolecular psychiatry2021
Nucleus accumbens fast-spiking interneurons in motivational and addictive behaviors.
Review in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 66 citations in OpenAlex.
- Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills.Nature human behaviour · 2024Trial
- Maternal pesticide exposure disrupts local inhibitory circuits in the reward pathway.Environment international · 2026Article
- Stimulant use disorder indicative of increased serum soluble intercellular adhesion molecule-1 concentrations with altered brain reward and interoceptive processing.Brain, behavior, and immunity · 2026Observational
- Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment.Nature communications · 2026Article
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
- Single-Cell Multi-Modal Differential Analysis of the Human Neo-Cortex in HIV Infection Reveals Similarities with Hallmarks of Alzheimer's Disease.Research square · 2025Article
- Mechanisms and interventions promoting healthy frontostriatal dynamics in obsessive-compulsive disorder.Nature communications · 2025Article
- Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Female Syrian hamster analyses of bremelanotide, a US FDA approved drug for the treatment of female hypoactive sexual desire disorder.Neuropharmacology · 2025Article
- Social hierarchy modulates drug reinforcement and protein phosphorylation in the nucleus accumbens.Frontiers in pharmacology · 2025Article
- ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice.Nature communications · 2024Article
- Theta and gamma modulation in the nucleus accumbens as drivers of neurophysiological responses to acute methamphetamine sensitization in mice.Experimental brain research · 2024Article
- The Perineuronal Net Protein Brevican Acts in Nucleus Accumbens Parvalbumin-Expressing Interneurons of Adult Mice to Regulate Excitatory Synaptic Inputs and Motivated Behaviors.Biological psychiatry · 2024Article
- VTA glutamatergic projections to the nucleus accumbens suppress psychostimulant-seeking behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking.Nature communications · 2024Article
- Microglia in neuroimmunopharmacology and drug addiction.Molecular psychiatry · 2024Review
- The nucleus accumbens in reward and aversion processing: insights and implications.Frontiers in behavioral neuroscience · 2024Review
- The nucleus accumbens shell: a neural hub at the interface of homeostatic and hedonic feeding.Frontiers in neuroscience · 2024Review
- Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The development of drug addiction is associated with functional adaptations within the reward circuitry, within which the nucleus accumbens (NAc) is anatomically positioned as an interface between motivational salience and behavioral output. The functional output of NAc is profoundly altered after exposure to drugs of abuse, and some of the functional changes continue to evolve during drug abstinence, contributing to numerous emotional and motivational alterations related drug taking, seeking, and relapse. As in most brain regions, the functional output of NAc is critically dependent on the dynamic interaction between excitation and inhibition. One of the most prominent sources of inhibition within the NAc arises from fast-spiking interneurons (FSIs). Each NAc FSI innervates hundreds of principal neurons, and orchestrates population activity through its powerful and sustained feedforward inhibition. While the role of NAc FSIs in the context of drug addiction remains poorly understood, emerging evidence suggests that FSIs and FSI-mediated local circuits are key targets for drugs of abuse to tilt the functional output of NAc toward a motivational state favoring drug seeking and relapse. In this review, we discuss recent findings and our conceptualization about NAc FSI-mediated regulation of motivated and cocaine-induced behaviors. We hope that the conceptual framework proposed in this review may provide a useful guidance for ongoing and future studies to determine how FSIs influence the function of NAc and related reward circuits, ultimately leading to addictive behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.