ArticleScientific reports2020
Exploring Natural Clusters of Chronic Migraine Phenotypes: A Cross-Sectional Clinical Study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility, Acceptability, and Pilot Testing of a Behavioral Intervention for Chronic Migraine
A Feasibility Clinical Trial Assessing Patient Preference, Optimum Combinations and Sequences of a Multicomponent, Virtually-Delivered Migraine Behavioral Intervention
Who cites it
13 citing papers in PubMed.
- Article
- Meningeal neuropeptide and neuroimmune interactions in the context of migraine.The journal of headache and pain · 2026Review
- Article
- Effect of Exercise on Chronic Tension-Type Headache and Chronic Migraine: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Exercise Patterns and Migraine Management: A Multifaceted Approach.American journal of lifestyle medicine · 2025Article
- Artificial intelligence terminology, methodology, and critical appraisal: A primer for headache clinicians and researchers.Headache · 2025Review
- Profiling chronic migraine patients according to clinical characteristics: a cluster analysis approach.Frontiers in neurology · 2025Article
- Article
- Incorporating Therapeutic Education and Exercise in Migraine Management: A Biobehavioral Approach.Journal of clinical medicine · 2024Review
- Medical calculators derived synthetic cohorts: a novel method for generating synthetic patient data.Scientific reports · 2024Article
- Deep and unbiased proteomics, pathway enrichment analysis, and protein-protein interaction of biomarker signatures in migraine.Therapeutic advances in chronic disease · 2024Article
- Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache.The journal of headache and pain · 2023Article
- Migraine phenotypes defined by disability, pain topography and autonomic features: association with serum vitamin D status.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterogeneity in chronic migraine (CM) presents significant challenge for diagnosis, management, and clinical trials. To explore naturally occurring clusters of CM, we utilized data reduction methods on migraine-related clinical dataset. Hierarchical agglomerative clustering and principal component analyses (PCA) were conducted to identify natural clusters in 100 CM patients using 14 migraine-related clinical variables. Three major clusters were identified. Cluster I (29 patients) - the severely impacted patient featured highest levels of depression and migraine-related disability. Cluster II (28 patients) - the minimally impacted patient exhibited highest levels of self-efficacy and exercise. Cluster III (43 patients) - the moderately impacted patient showed features ranging between Cluster I and II. The first 5 principal components (PC) of the PCA explained 65% of variability. The first PC (eigenvalue 4.2) showed one major pattern of clinical features positively loaded by migraine-related disability, depression, poor sleep quality, somatic symptoms, post-traumatic stress disorder, being overweight and negatively loaded by pain self-efficacy and exercise levels. CM patients can be classified into three naturally-occurring clusters. Patients with high self-efficacy and exercise levels had lower migraine-related disability, depression, sleep quality, and somatic symptoms. These results may ultimately inform different management strategies.
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Registered trials
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